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公开(公告)号：WO2021069524A1
公开(公告)日：2021-04-15
申请号：PCT/EP2020/078174
申请日：2020-10-07
IPC分类号： G01N33/50 , G01N33/543 , G01N33/68
摘要： Methods, devices and kits for the detection and quantification of XBP1s and XBP1u are described.
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公开(公告)号：WO2015049390A2
公开(公告)日：2015-04-09
申请号：PCT/EP2014071354
申请日：2014-10-06
申请人： RANDOX TEORANTA
IPC分类号： G01N33/574
CPC分类号： G01N33/6893 , G01N2333/4716 , G01N2333/523 , G01N2800/347 , G01N2800/52 , G01N2800/60
摘要： The present invention provides methods and solid state devices for detecting and staging chronic kidney disease in a patient, where the levels of biomarkers in a sample obtained from a patient are elevated or reduced compared to the levels in a sample obtained from healthy subject. The invention also relates to the use of methods and solid state devices for measurement of specific biological markers for determining the efficacy of a treatment for chronic kidney disease and for determining a drug treatment protocol for a subject suffering from chronic kidney disease.
摘要翻译： 本发明提供了用于检测和分期患者慢性肾脏疾病的方法和固态装置，其中从患者获得的样品中的生物标志物水平与从健康对象获得的样品中的水平相比升高或降低。 本发明还涉及用于测量特定生物标志物的方法和固态装置的用途，用于确定治疗慢性肾病的功效和用于确定患有慢性肾病的受试者的药物治疗方案。
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公开(公告)号：WO2022207863A1
公开(公告)日：2022-10-06
申请号：PCT/EP2022/058691
申请日：2022-03-31
发明人： FITZGERALD, Peter , LAMONT, John Victor , MCCONNELL, Ivan , RICHARDSON, Ciaran , LOWRY, Philip , CURRY, Jim
IPC分类号： G01N33/543 , G01N33/569 , G01N2333/165 , G01N33/54353 , G01N33/56983
摘要： The present invention relates to a method of detecting the presence of an antibody in a samples obtained from a subject, wherein said antibody has affinity for a coronavirus antigen, or portion thereof. The present invention also relates to a substrate having immobilised on its surface said coronavirus antigen and methods for producing said substrate.
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公开(公告)号：WO2018229144A1
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065688
申请日：2018-06-13
IPC分类号： G01N33/68
摘要： The current invention provides novel combinations of biomarkers for use in methods for the diagnosis and differentiation of stroke sub-types. These methods may be enabled by way of substrates comprising immobilised probes to said biomarkers, facilitating their detection in samples taken from patients suspected of having had or currently suffering from a stroke.
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公开(公告)号：WO2018228935A1
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065142
申请日：2018-06-08
IPC分类号： G01N33/68
摘要： Change of reference standards leads to improved biomarker-based methods of stroke diagnosis.
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公开(公告)号：WO2015049390A3
公开(公告)日：2015-04-09
申请号：PCT/EP2014/071354
申请日：2014-10-06
申请人： RANDOX TEORANTA
IPC分类号： G01N33/574 , G01N33/68
摘要： The present invention provides methods and solid state devices for detecting and staging chronic kidney disease in a patient, where the levels of biomarkers in a sample obtained from a patient are elevated or reduced compared to the levels in a sample obtained from healthy subject. The invention also relates to the use of methods and solid state devices for measurement of specific biological markers for determining the efficacy of a treatment for chronic kidney disease and for determining a drug treatment protocol for a subject suffering from chronic kidney disease.
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公开(公告)号：WO2022200573A1
公开(公告)日：2022-09-29
申请号：PCT/EP2022/057927
申请日：2022-03-25
IPC分类号： G01N33/68
摘要： The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.
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公开(公告)号：WO2022157504A1
公开(公告)日：2022-07-28
申请号：PCT/GB2022/050169
申请日：2022-01-21
摘要： There is provided a bracket for a biological sample analyser. The bracket comprises a base and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.
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公开(公告)号：WO2018096049A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/080247
申请日：2017-11-23
摘要： Described are methods and kits for diagnosing stroke using GFAP derivatives.
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公开(公告)号：WO2018095872A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/079822
申请日：2017-11-20
发明人： FITZGERALD, Stephen Peter , MCCONNELL, Ivan , RICHARDSON, Ciaran , LAMONT, John , MAKRIS, Konstantinos
IPC分类号： G01N33/68
摘要： The use of glial fibrillary acidic protein (GFAP) as a marker of pernicious stroke is described. The method can also involve subjecting a patient to a brain scan.
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