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    SAXAGLIPTIN SOLID DISPERSION
    9.
    发明申请
    SAXAGLIPTIN SOLID DISPERSION 审中-公开
    SAXAGLIPTIN固体分散体

    公开(公告)号：WO2013171766A3

    公开(公告)日：2014-01-03

    申请号：PCT/IN2013000311

    申请日：2013-05-13

    申请人： HETERO RESEARCH FOUNDATION ,  PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  SUBASH CHANDER REDDY KESIREDDY ,  VAMSI KRISHNA BANDI

    发明人： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  SUBASH CHANDER REDDY KESIREDDY ,  VAMSI KRISHNA BANDI

    IPC分类号： A61K31/403

    CPC分类号： A61K9/146 ,  A61K31/403

    摘要： The present invention provides a novel amorphous solid dispersion of saxagliptin in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it. In a preferred embodiment, the process for the preparation of amorphous solid dispersion of saxagliptin in combination with a pharmaceutically acceptable carrier comprises: preparing a solution comprising a mixture of saxagliptin and one or more pharmaceutically acceptable carriers selected from copovidone, ethyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol or soluplus in a solvent; and removing the solvent to obtain amorphous solid dispersion of saxagliptin in combination with a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供了一种新颖的沙利格霉素无定形固体分散体与药学上可接受的载体，其制备方法和包含其的药物组合物。 在优选的实施方案中，用于制备沙格列汀与药学上可接受的载体组合的无定形固体分散体的方法包括：制备包含沙格列汀和一种或多种药学上可接受的载体的混合物的溶液，所述载体选自共聚维酮，乙基纤维素，羟丙基甲基纤维素， 聚乙二醇或溶剂在溶剂中; 并除去溶剂以获得与可药用载体组合的沙格列汀的无定形固体分散体。

    SUNITINIB MALATE SOLID DISPERSION
    10.
    发明申请
    SUNITINIB MALATE SOLID DISPERSION 审中-公开
    SUNITINIB MALATE固体分散体

    公开(公告)号：WO2013160916A1

    公开(公告)日：2013-10-31

    申请号：PCT/IN2013/000280

    申请日：2013-04-25

    申请人： HETERO RESEARCH FOUNDATION ,  PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  SRINIVASA RAO, Thungathurthy ,  VAMSI KRISHNA, Bandi

    发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  SRINIVASA RAO, Thungathurthy ,  VAMSI KRISHNA, Bandi

    IPC分类号： A61K31/403

    CPC分类号： A61K9/146 ,  A61K31/404

    摘要： The present invention provides a novel amorphous solid dispersion of sunitinib malate in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it. In one aspect, the present invention provides amorphous solid dispersion of sunitinib malate in combination with a pharmaceutically acceptable carrier. In another aspect, the present invention there is provided a process for the preparation of amorphous solid dispersion of sunitinib malate in combination with a pharmaceutically acceptable carrier, which comprises: a) preparing a solution comprising a mixture of sunitinib malate and one or more pharmaceutically acceptable carriers selected form copovidone, span 20, ethyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol or soluplus in water; and b) subjecting the resulting solution to freeze drying to obtain amorphous solid dispersion of sunitinib malate in combination with a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供了苹果酸舒尼替尼与药学上可接受的载体，其制备方法和包含其的药物组合物的新型无定形固体分散体。 一方面，本发明提供苹果酸舒尼替尼与药学上可接受的载体的无定形固体分散体。 在另一方面，本发明提供了一种制备苹果酸舒尼替尼与药学上可接受的载体的无定形固体分散体的方法，其包括：a）制备包含苹果酸舒尼替尼与一种或多种药学上可接受的混合物的溶液 选自形式的共聚维生素，跨度20，乙基纤维素，羟丙基甲基纤维素，聚乙二醇或水溶液中的载体; 和b）使所得溶液冷冻干燥以获得苹果酸舒尼替尼与药学上可接受的载体的无定形固体分散体。