公开(公告)号：WO2007021970A3

公开(公告)日：2008-10-09

申请号：PCT/US2006031439

申请日：2006-08-14

Applicant: PRAECIS PHARM INC ,  TAN HEOW MENG ,  YE MING ,  MCGRATH THOMAS F ,  JOHNSTON KEVIN A ,  MICALIZZI MARIA ,  MCKENNA PATRICK ,  REDMON MARTIN PATRICK ,  VUPPALA MURALI K ,  MUSSO GARY F

Inventor： TAN HEOW MENG ,  YE MING ,  MCGRATH THOMAS F ,  JOHNSTON KEVIN A ,  MICALIZZI MARIA ,  MCKENNA PATRICK ,  REDMON MARTIN PATRICK ,  VUPPALA MURALI K ,  MUSSO GARY F

IPC: A61K47/48

CPC classification number: A61K31/485 ,  A61K45/06 ,  A61K47/61 ,  A61K2300/00

Abstract: The present invention provides pharmaceutical formulations characterized by improved stability of the pharmaceutically active compounds contained therein, methods for preparing the same, and methods of use thereof. The pharmaceutical compositions of the present invention comprise a stable water-insoluble complex of a pharmaceutically active compound and a carrier macromolecule. The advantages of the pharmaceutical compositions of the invention include, for example, the increased stability of a pharmaceutically active compound contained therein.

Abstract translation: 本发明提供药物制剂，其特征在于其中所含的药物活性化合物的稳定性提高，其制备方法及其使用方法。 本发明的药物组合物包含药物活性化合物和载体大分子的稳定的水不溶性复合物。 本发明的药物组合物的优点包括例如其中所含的药物活性化合物的稳定性增加。

公开(公告)号：WO2007021970A2

公开(公告)日：2007-02-22

申请号：PCT/US2006/031439

申请日：2006-08-14

Applicant: PRAECIS PHARMACEUTICALS, INC. ,  TAN, Heow, Meng ,  YE, Ming ,  MCGRATH, Thomas, F. ,  JOHNSTON, Kevin, A. ,  MICALIZZI, Maria ,  MCKENNA, Patrick ,  REDMON, Martin, Patrick ,  VUPPALA, Murali, K. ,  MUSSO, Gary, F.

Inventor： TAN, Heow, Meng ,  YE, Ming ,  MCGRATH, Thomas, F. ,  JOHNSTON, Kevin, A. ,  MICALIZZI, Maria ,  MCKENNA, Patrick ,  REDMON, Martin, Patrick ,  VUPPALA, Murali, K. ,  MUSSO, Gary, F.

IPC: A61K47/48

CPC classification number: A61K31/485 ,  A61K45/06 ,  A61K47/61 ,  A61K2300/00

Abstract: The present invention provides pharmaceutical formulations characterized by improved stability of the pharmaceutically active compounds contained therein, methods for preparing the same, and methods of use thereof. The pharmaceutical compositions of the present invention comprise a stable water-insoluble complex of a pharmaceutically active compound and a carrier macromolecule. The advantages of the pharmaceutical compositions of the invention include, for example, the increased stability of a pharmaceutically active compound contained therein.

Abstract translation: 本发明提供药物制剂，其特征在于其中所含的药物活性化合物的稳定性提高，其制备方法及其使用方法。 本发明的药物组合物包含药物活性化合物和载体大分子的稳定的水不溶性复合物。 本发明的药物组合物的优点包括例如其中所含的药物活性化合物的稳定性增加。