公开(公告)号：WO2004085442A3

公开(公告)日：2004-12-16

申请号：PCT/EP2004003140

申请日：2004-03-24

Applicant: CENTRE NAT RECH SCIENT ,  UNIV PARIS DESCARTES ,  UNIV HAVRE ,  REINAUD OLIVIA ,  JABIN IVAN ,  DARBOST ULRICH ,  XU-LI YUN ,  REDON SOPHIE

Inventor： REINAUD OLIVIA ,  JABIN IVAN ,  DARBOST ULRICH ,  XU-LI YUN ,  REDON SOPHIE

IPC: A61P35/00 ,  C07D498/16 ,  C07D498/22 ,  A61K31/555

CPC classification number: C07D498/22

Abstract: The present invention relates to new calix arene compounds of formula (1). It also relates to their process of preparation. The present invention also relates to complexes between a compound of formula (1) and an element chosen among a metal, an actinide, a radioelement, a cationic guest or an anionic guest. The present invention also relates to a pharmaceutical composition comprising a compound of formula (I) in association with a pharmaceutically acceptable carrier. The present invention also relates to a process of preparation of water-soluble compounds, comprising a reaction of nitration or sulfonation, and optionally a reaction of sulfonation or nitration, particularly of compounds of formula (1), and also to the compounds such as obtained.

Abstract translation: 本发明涉及式（1）的新的杯芳烃化合物。 它还涉及其制备方法。 本发明还涉及式（1）化合物与选自金属，锕系元素，放射性元素，阳离子客体或阴离子客体的元素之间的配合物。 本发明还涉及包含与药学上可接受的载体结合的式（I）化合物的药物组合物。 本发明还涉及一种制备水溶性化合物的方法，包括硝化或磺化反应，以及任选的磺化或硝化反应，特别是式（1）化合物的反应，以及所得化合物 。

公开(公告)号：WO2004085442A2

公开(公告)日：2004-10-07

申请号：PCT/EP2004/003140

申请日：2004-03-24

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE RENE DESCARTES-PARIS V ,  UNIVERSITE DU HAVRE ,  REINAUD, Olivia ,  JABIN, Ivan ,  DARBOST, Ulrich ,  XU-LI, Yun ,  REDON, Sophie

Inventor： REINAUD, Olivia ,  JABIN, Ivan ,  DARBOST, Ulrich ,  XU-LI, Yun ,  REDON, Sophie

IPC: C07D498/22

CPC classification number: C07D498/22

Abstract: The present invention relates to new calix arene compounds of formula (1). It also relates to their process of preparation. The present invention also relates to complexes between a compound of formula (1) and an element chosen among a metal, an actinide, a radioelement, a cationic guest or an anionic guest. The present invention also relates to a pharmaceutical composition comprising a compound of formula (I) in association with a pharmaceutically acceptable carrier. The present invention also relates to a process of preparation of water-soluble compounds, comprising a reaction of nitration or sulfonation, and optionally a reaction of sulfonation or nitration, particularly of compounds of formula (1), and also to the compounds such as obtained.

Abstract translation: 本发明涉及式（1）的新型杯芳烃化合物。 它也涉及他们的准备过程。 本发明还涉及式（1）化合物与选自金属，act系元素，放射性元素，阳离子客体或阴离子客体的元素之间的络合物。 本发明还涉及包含式（I）化合物和药学上可接受的载体的药物组合物。 本发明还涉及一种制备水溶性化合物的方法，该方法包括硝化或磺化反应，和任选的磺化或硝化反应，特别是式（1）化合物的反应，还涉及例如获得的化合物

公开(公告)号：WO2004085441A1

公开(公告)日：2004-10-07

申请号：PCT/EP2003/003045

申请日：2003-03-24

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE RENE DESCARTES-PARIS V ,  UNIVERSITE DU HAVRE ,  REINAUD, Olivia ,  JABIN, Ivan ,  DARBOST, Ulrich ,  XU-LI, Yun ,  REDON, Sophie

Inventor： REINAUD, Olivia ,  JABIN, Ivan ,  DARBOST, Ulrich ,  XU-LI, Yun ,  REDON, Sophie

IPC: C07D498/22

CPC classification number: C07D498/22

Abstract: The present invention relates to new calix arene compounds of formula (I). It also relates to their process of preparation. The present invention also relates to complexes between a compound of formula (I) and an element chosen among a metal, an actinide, a radioelement, a cationic guest or an anionic guest. The present invention also relates to a pharmaceutical composition comprising a compound of formula (I) in association with a pharmaceutically acceptable carrier. The present invention also relates to a process of preparation of water-soluble compounds, comprising a reaction of nitration or sulfonation or nitration, particularly of compounds of formula (I), and also to the compounds such as obtained.

Abstract translation: 本发明涉及式（I）的新的杯芳烃化合物。 它还涉及其制备方法。 本发明还涉及式（I）化合物与选自金属，锕系元素，放射性元素，阳离子客体或阴离子客体的元素之间的配合物。 本发明还涉及包含与药学上可接受的载体结合的式（I）化合物的药物组合物。 本发明还涉及一种制备水溶性化合物的方法，其包括硝化或磺化或硝化反应，特别是式（I）化合物的反应，以及所得化合物。