公开(公告)号：WO2022245814A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/029620

申请日：2022-05-17

Applicant: ROME THERAPEUTICS, INC.

Inventor： KAPELLER-LIBERMANN, Rosana ,  ROMERO, Donna L. ,  ZALLER, Dennis

IPC: C07F9/6561 ,  C07H19/20 ,  A61K31/675 ,  A61P35/00

Abstract: The invention provides methods and compositions for treating medical disorders, such as cancer, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a substituted 4-fluoro-2,5-dihydrofuranyl phosphonic acid or related compound.

公开(公告)号：WO2022271878A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034603

申请日：2022-06-22

Applicant: ROME THERAPEUTICS, INC.

Inventor： ROMERO, Donna, L. ,  SAUNDERS, Oliver ,  BISACCHI, Gregory, Stuart ,  ZALLER, Dennis

IPC: A61K31/675 ,  C07H19/20 ,  C07H19/213 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

Abstract: The invention provides substituted 4-ethynyl-3-hydroxy-tetrahydrofuranyl-adenine phosphoramidates and related compounds, pharmaceutical compositions, their use for inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase activity, and their use in the treatment of medical disorders, such as cancer.

公开(公告)号：WO2022271880A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034605

申请日：2022-06-22

Applicant: ROME THERAPEUTICS, INC.

Inventor： ROMERO, Donna L. ,  SAUNDERS, Oliver ,  BISACCHI, Gregory Stuart ,  ZALLER, Dennis ,  KAPELLER-LIBERMANN, Rosana

IPC: A61K31/675 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02

Abstract: The invention provides methods and compositions for treating medical disorders, such as cancer, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a substituted adeninyl-propyloxy phosphonic acid or related compound similar to tenofovir and tenofovir prodrugs like tenofovir alafenamide, tenofovir disoproxil fumarate, or tenofovir exalidex.