公开(公告)号：WO2012118749A1

公开(公告)日：2012-09-07

申请号：PCT/US2012/026762

申请日：2012-02-27

Applicant: GENTEX CORPORATION ,  ROTH, Mark, R. ,  RIZK, Peter, N. ,  MINIKEY, Danny, L. ,  FILIPIAK, Kenneth, R. ,  TUTTLE, Darin, D. ,  FRYE, Kent, H.

Inventor： ROTH, Mark, R. ,  RIZK, Peter, N. ,  MINIKEY, Danny, L. ,  FILIPIAK, Kenneth, R. ,  TUTTLE, Darin, D. ,  FRYE, Kent, H.

IPC: B60R1/04

CPC classification number: B60R1/12 ,  B60R1/04 ,  B60R11/04 ,  B60R2011/0033

Abstract: A rearview device mounting assembly including a mount configured to be operably coupled to a windshield. A first support extends downward from the mount. A second support is rotatably connected with the first support and is rotatable about a first axis of rotation. The second support includes a carrier that extends substantially orthogonal to the first axis of rotation. A rearview device assembly is operably connected to the carrier. The rearview device assembly is substantially vertically rotatable about the carrier and substantially horizontally rotatable about the first support.

Abstract translation: 一种后视装置安装组件，包括构造成可操作地联接到挡风玻璃的安装座。 第一个支架向下延伸。 第二支撑件可旋转地与第一支撑件连接并且可围绕第一旋转轴线旋转。 第二支撑件包括基本上垂直于第一旋转轴线延伸的载体。 后视装置组件可操作地连接到载体。 后视装置组件基本可垂直地绕托架旋转并且围绕第一支撑件基本水平地可旋转。

公开(公告)号：WO2008040002A3

公开(公告)日：2009-07-09

申请号：PCT/US2007079948

申请日：2007-09-28

Applicant: HUTCHINSON FRED CANCER RES ,  ROTH MARK B ,  BUDDE MARK

Inventor： ROTH MARK B ,  BUDDE MARK

IPC: A61K31/095 ,  A01N1/00 ,  A61K33/04 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P41/00 ,  A61P43/00

CPC classification number: A61K33/04 ,  A01N1/0205 ,  A01N1/0226 ,  A61K31/095 ,  A61K33/00 ,  A61K45/06

Abstract: The present invention generally relates to the modulation of hypoxia- inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the prevention, pretreatment, and/or treatment of conditions or states associated with HIF, such as hypoxia- and ischemia-related conditions and the induction of stasis.

Abstract translation: 本发明一般涉及使用本文公开的化合物和方法调节缺氧诱导因子（HIF）。 这些化合物和方法可以用于预防，预处理和/或治疗与HIF相关的状况或状态，例如缺氧和缺血相关病症以及诱导停滞。

公开(公告)号：WO2008089439A2

公开(公告)日：2008-07-24

申请号：PCT/US2008/051486

申请日：2008-01-18

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  ROTH, Mark, B. ,  MILLER, Dana, L.

Inventor： ROTH, Mark, B. ,  MILLER, Dana, L.

CPC classification number: A61K45/06 ,  A61K31/05 ,  A61K31/11 ,  A61K31/352 ,  A61K31/455 ,  A61K33/04 ,  A61K2300/00

Abstract: The present invention concerns the use of active compounds, including chalcogenides and sirtuin-modulating compounds, either alone or in combination for increasing or enhancing survivability and/or longevity in biological matter. In general aspects, the chalcogenides and other active compounds may modulate one or more sirtuin proteins. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

Abstract translation: 本发明涉及活性化合物，包括硫属化物和沉默调节蛋白的调节化合物，其单独或组合用于增加或提高生物物质的生存能力和/或寿命。 在一般方面，硫属化物和其它活性化合物可以调节一种或多种沉默调节蛋白。 它包括组合物，方法，制品和用于提高任何这些生物材料的生存性的装置，以便保存和/或保护它们。 在具体实施方案中，还存在用于衰老或压力，糖尿病，肥胖症，神经变性疾病，心血管疾病，血液凝固病症，炎症，癌症，器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停跳的治疗方法和装置， 使用所述活性化合物的神经变性，低体温和癌症。

公开(公告)号：WO2006086772A2

公开(公告)日：2006-08-17

申请号：PCT/US2006/005032

申请日：2006-02-10

Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  ROTH, Mark, J. ,  HUPPI, Konrad

Inventor： ROTH, Mark, J. ,  HUPPI, Konrad

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12N15/113 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136

Abstract: The invention relates to method and compositions for treating and diagnosing cancer, in particular β-catenin related cancers. In general, the methods include administering RNAi constructs. The invention further relates to methods of identifying CTNNBl related cancer therapeutics.

Abstract translation: 本发明涉及用于治疗和诊断癌症的方法和组合物，特别是β-连环蛋白相关的癌症。 通常，所述方法包括施用RNAi构建体。 本发明还涉及鉴定CTNNB1相关癌症治疗剂的方法。

公开(公告)号：WO2006023458A9

公开(公告)日：2006-04-06

申请号：PCT/US2005029019

申请日：2005-08-13

Applicant: INTEL CORP ,  SUNDARARAJAN NARAYAN ,  SUN LEI ,  SU XING ,  YAMAKAWA MINEO ,  JINGWU ZHANG ,  CHAN SELENA ,  BERLIN ANDREW ,  KOO TAE-WOONG ,  ROTH MARK ,  GAFEN PHIL

Inventor： SUNDARARAJAN NARAYAN ,  SUN LEI ,  SU XING ,  YAMAKAWA MINEO ,  JINGWU ZHANG ,  CHAN SELENA ,  BERLIN ANDREW ,  KOO TAE-WOONG ,  ROTH MARK ,  GAFEN PHIL

IPC: G01N33/68 ,  G01N21/65

CPC classification number: G01N33/6851 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  Y02A90/26

Abstract: Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diognosis, prognosis and drug efficacy studies, emzymatic activity profiling and assays.

Abstract translation: 本发明的实施方案提供了使用表面增强拉曼（SERS）和拉曼光谱法检测，鉴定，区分和定量蛋白质和肽的修饰状态的装置和方法。 本发明的实施方案的应用包括例如蛋白质组广泛的修饰分析和分析，其应用于疾病预后，预后和药物功效研究，酶活性分析和测定。

公开(公告)号：WO2005039291A2

公开(公告)日：2005-05-06

申请号：PCT/US2004/035289

申请日：2004-10-22

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  ROTH, Mark, B.

Inventor： ROTH, Mark, B.

IPC: A01N1/02

CPC classification number: C12N5/00 ,  A01N1/02 ,  A01N1/0221 ,  C12N2500/02

Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in cells. It includes methods and apparatuses for achieving stasis in cells, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for storing platelets is provided.

Abstract translation: 本发明涉及氧拮抗剂在细胞中诱导停滞的用途。 它包括用于在细胞中实现停滞的方法和装置，以保存和/或保护它们。 在具体的实施方案中，提供了用于储存血小板的保存方法和设备。

公开(公告)号：WO2008089439A3

公开(公告)日：2013-10-31

申请号：PCT/US2008051486

申请日：2008-01-18

Applicant: HUTCHINSON FRED CANCER RES ,  ROTH MARK B ,  MILLER DANA L

Inventor： ROTH MARK B ,  MILLER DANA L

IPC: A61K31/05 ,  A61K31/06 ,  A61K31/11 ,  A61K31/352 ,  A61K31/455 ,  A61K33/04 ,  A61K45/06

CPC classification number: A61K45/06 ,  A61K31/05 ,  A61K31/11 ,  A61K31/352 ,  A61K31/455 ,  A61K33/04 ,  A61K2300/00

Abstract: The present invention concerns the use of active compounds, including chalcogenides and sirtuin-modulating compounds, either alone or in combination for increasing or enhancing survivability and/or longevity in biological matter. In general aspects, the chalcogenides and other active compounds may modulate one or more sirtuin proteins. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

Abstract translation: 本发明涉及活性化合物，包括硫属化物和沉默调节蛋白的调节化合物，其单独或组合用于增加或提高生物物质的生存能力和/或寿命。 在一般方面，硫属化物和其它活性化合物可调节一种或多种沉默调节蛋白。 它包括组合物，方法，制品和用于提高任何这些生物材料的生存性的装置，以便保存和/或保护它们。 在具体实施方案中，还存在用于衰老或压力，糖尿病，肥胖症，神经变性疾病，心血管疾病，血液凝固病症，炎症，癌症，器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停跳的治疗方法和装置， 使用所述活性化合物的神经变性，低体温和癌症。

公开(公告)号：WO2012118749A8

公开(公告)日：2012-11-15

申请号：PCT/US2012026762

申请日：2012-02-27

Applicant: GENTEX CORP ,  ROTH MARK R ,  RIZK PETER N ,  MINIKEY DANNY L JR ,  FILIPIAK KENNETH R ,  TUTTLE DARIN D ,  FRYE KENT H

Inventor： ROTH MARK R ,  RIZK PETER N ,  MINIKEY DANNY L JR ,  FILIPIAK KENNETH R ,  TUTTLE DARIN D ,  FRYE KENT H

IPC: B60R1/04

CPC classification number: B60R1/12 ,  B60R1/04 ,  B60R11/04 ,  B60R2011/0033

Abstract: A rearview device mounting assembly including a mount configured to be operably coupled to a windshield. A first support extends downward from the mount. A second support is rotatably connected with the first support and is rotatable about a first axis of rotation. The second support includes a carrier that extends substantially orthogonal to the first axis of rotation. A rearview device assembly is operably connected to the carrier. The rearview device assembly is substantially vertically rotatable about the carrier and substantially horizontally rotatable about the first support.

Abstract translation: 一种后视镜装置安装组件，其包括构造成可操作地联接至挡风玻璃的安装座。 第一支撑从支架向下延伸。 第二支撑件与第一支撑件可旋转地连接并且可围绕第一旋转轴线旋转。 第二支撑件包括基本垂直于第一旋转轴线延伸的支架。 后视装置组件可操作地连接到载体。 后视装置组件围绕载体基本上竖直地旋转并且能够围绕第一支撑件大致水平地旋转。

公开(公告)号：WO2012118788A8

公开(公告)日：2012-09-07

申请号：PCT/US2012/026901

申请日：2012-02-28

Applicant: GENTEX CORPORATION ,  STEEL, Robert ,  ROTH, Mark, R. ,  MINIKEY, Danny, L., Jr.

Inventor： STEEL, Robert ,  ROTH, Mark, R. ,  MINIKEY, Danny, L., Jr.

IPC: B60R1/04

Abstract: An interior rearview device support assembly having a support member including a connecting end and a pivot end. A rearview device housing defines an internal cavity and includes a socket. The pivot end of the support member is coupled with the socket and is pivotable relative thereto. A sensor device is disposed inside the rearview device housing and is coupled to the support member.

公开(公告)号：WO2011041301A3

公开(公告)日：2011-08-18

申请号：PCT/US2010050528

申请日：2010-09-28

Applicant: GENTEX CORP ,  LEE ETHAN J ,  LEE DANIEL B ,  HENDRICKS MICHAEL G ,  ROTH MARK R ,  MYERS CRAIG R ,  POE G BRUCE ,  BLAKER DAVID A ,  SCHAUDEL CARSTEN ,  VAN VUUREN MARK A ,  VANDERPLOEG JOHN A

Inventor： LEE ETHAN J ,  LEE DANIEL B ,  HENDRICKS MICHAEL G ,  ROTH MARK R ,  MYERS CRAIG R ,  POE G BRUCE ,  BLAKER DAVID A ,  SCHAUDEL CARSTEN ,  VAN VUUREN MARK A ,  VANDERPLOEG JOHN A

IPC: B60R1/00 ,  B60R1/04 ,  G02F1/13

CPC classification number: B60R1/12 ,  B60R2001/1253 ,  G02F1/13336 ,  G02F2201/44

Abstract: A multi-display vehicular rearview mirror system (2600) includes an electrochromic (EC) glass element (2603) and a plurality of liquid crystal displays (LCDs) ( 2605a, 2605b, 2605c) positioned behind EC element (2603). A plurality of light emitting diodes (LEDs) (2610a, 2610b, 2610c) are used for providing backlighting for each respective LCD of the plurality of LCDs such that the LCDs utilize a plurality of imaging devices (2717, 2719, 2721) for forming substantially a single image across the plurality of LCDs (2605a, 2605b, 2605c).

Abstract translation: 多显示车辆后视镜系统（2600）包括位于EC元件（2603）后面的电致变色（EC）玻璃元件（2603）和多个液晶显示器（LCD）（2605a，2605b，2605c）。 多个发光二极管（LED）（2610a，2610b，2610c）用于为多个LCD中的每个LCD提供背光，使得LCD利用多个成像装置（2717,2719,2721），用于基本上形成 跨越多个LCD（2605a，2605b，2605c）的单个图像。