公开(公告)号：WO2012177653A2

公开(公告)日：2012-12-27

申请号：PCT/US2012/043172

申请日：2012-06-19

Applicant: ST. LOUIS UNIVERSITY ,  KAMINSKI, Henry ,  KUSNER, Linda ,  SATIJA, Namita

Inventor： KAMINSKI, Henry ,  KUSNER, Linda ,  SATIJA, Namita

IPC: A61K38/17 ,  C07K19/00 ,  A61K39/44 ,  A61P21/00 ,  A61P21/04

CPC classification number: A61K47/48246 ,  A61K38/00 ,  A61K47/64 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/005 ,  C07K14/43527 ,  C07K14/46 ,  C07K14/70596 ,  C07K14/78 ,  C07K14/811 ,  C07K16/286 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/50 ,  C12N2740/16222 ,  C12N2760/20122 ,  Y02A50/469

Abstract: Compositions and methods for targeting therapeutic agents to neuromuscular junctions are disclosed. Also disclosed are methods for treating diseases and conditions affecting the neuromuscular junction. Compositions include a neuromuscular junction targeting peptide coupled to a therapeutic agent. Compositions may further include a linker peptide. Methods for targeting therapeutic agents to neuromuscular junctions and treating diseases and conditions affecting the neuromuscular junction include administering a composition including a neuromuscular junction targeting peptide coupled to a therapeutic agent.

Abstract translation: 公开了将治疗剂靶向神经肌肉接头的组合物和方法。 还公开了治疗影响神经肌肉接头的疾病和病症的方法。 组合物包括与治疗剂偶联的神经肌肉接头靶向肽。 组合物还可以包括接头肽。 将治疗剂靶向神经肌肉接头并治疗影响神经肌肉接头的疾病和病症的方法包括施用包含与治疗剂偶联的神经肌肉接头靶向肽的组合物。

公开(公告)号：WO2012177653A3

公开(公告)日：2013-05-10

申请号：PCT/US2012043172

申请日：2012-06-19

Applicant: UNIV ST LOUIS ,  KAMINSKI HENRY ,  KUSNER LINDA ,  SATIJA NAMITA

Inventor： KAMINSKI HENRY ,  KUSNER LINDA ,  SATIJA NAMITA

IPC: A61K47/00 ,  A61K31/00

CPC classification number: A61K47/48246 ,  A61K38/00 ,  A61K47/64 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/005 ,  C07K14/43527 ,  C07K14/46 ,  C07K14/70596 ,  C07K14/78 ,  C07K14/811 ,  C07K16/286 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/50 ,  C12N2740/16222 ,  C12N2760/20122

Abstract: Compositions and methods for targeting therapeutic agents to neuromuscular junctions are disclosed. Also disclosed are methods for treating diseases and conditions affecting the neuromuscular junction. Compositions include a neuromuscular junction targeting peptide coupled to a therapeutic agent. Compositions may further include a linker peptide. Methods for targeting therapeutic agents to neuromuscular junctions and treating diseases and conditions affecting the neuromuscular junction include administering a composition including a neuromuscular junction targeting peptide coupled to a therapeutic agent.

Abstract translation: 公开了将治疗剂靶向神经肌肉接头的组合物和方法。 还公开了治疗影响神经肌肉接头的疾病和病症的方法。 组合物包括与治疗剂偶联的神经肌肉接头靶向肽。 组合物还可以包括连接肽。 将治疗剂靶向神经肌肉接头并治疗影响神经肌肉接头的疾病和病症的方法包括施用包含与治疗剂偶联的神经肌肉接头靶向肽的组合物。