公开(公告)号：WO2012048316A3

公开(公告)日：2012-08-02

申请号：PCT/US2011055561

申请日：2011-10-10

Applicant: IMMUNE DISEASE INST INC ,  RAO ANJANA ,  HOGAN PATRICK ,  SHARMA SONIA

Inventor： RAO ANJANA ,  HOGAN PATRICK ,  SHARMA SONIA

IPC: A61K31/713 ,  C07H21/04

CPC classification number: C12N15/113 ,  C12N2310/14

Abstract: Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of septin 4 (SEPT 4) and septin 5 (SEPT 5) proteins involved in the calcineurin/NFAT axis and T-cell activation.

Abstract translation: 本发明的实施方案涉及通过抑制septin 4（SEPT 4）和septin 5（SEPT 5）的表达或活性来调节NFAT活性，调节商店运行的Ca 2+进入细胞并治疗和/或预防活动过度或不适当的免疫应答。 涉及钙调磷酸酶/ NFAT轴和T细胞活化的蛋白质。

公开(公告)号：WO2012048316A2

公开(公告)日：2012-04-12

申请号：PCT/US2011/055561

申请日：2011-10-10

Applicant: IMMUNE DISEASE INSTITUTE, INC. ,  RAO, Anjana ,  HOGAN, Patrick ,  SHARMA, Sonia

Inventor： RAO, Anjana ,  HOGAN, Patrick ,  SHARMA, Sonia

IPC: A61K48/00

CPC classification number: C12N15/113 ,  C12N2310/14

Abstract: Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca 2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of septin 4 (SEPT 4) and septin 5 (SEPT 5) proteins involved in the calcineurin/NFAT axis and T-cell activation.

Abstract translation: 本发明的实施方案涉及通过抑制septin 4（SEPT 4）和septin 5（SEPT 5）的表达或活性来调节NFAT活性，调节储存操作的Ca 2+进入细胞并治疗和/或预防多动症或不适当的免疫应答。 参与钙调神经磷酸酶/ NFAT轴的蛋白质和T细胞活化。