公开(公告)号：WO03008367A3

公开(公告)日：2003-04-10

申请号：PCT/US0222631

申请日：2002-07-16

申请人： NOVARTIS AG ,  GIRGIS MICHAEL JOHN ,  SHEKHAR RATNA

发明人： GIRGIS MICHAEL JOHN ,  SHEKHAR RATNA

IPC分类号： C07C51/235 ,  C07C51/255 ,  C07C63/04 ,  C07C233/81

CPC分类号： C07C51/235 ,  C07C63/04

摘要： A low temperature process for preparing an aromatic acid having formula (I), said process comprising reacting an aromatic aldehyde having formula (II) with a gas having an oxygen content of 1 to 100 weight percent, based on the total weight of the gas, at a temperature of about 20 °C to less than 100 °C in the presence of the supported Group VIII metal catalyst, and a solvent having a flash point greater than 95 °C and/or a melting point less than 55 °C, provided that the flash point of the solvent is greater than the reaction temperature, wherein R and R are independently selected from the group consisting of hydrogen and a C1-C8 linear, branched or cyclic alkyl group. The process of the invention yields an aromatic acid in excellent yield, and (i) does not involve the use of deleterious oxidizing agents; (ii) is essentially free of by-products; and (iii) is accomplished at a temperature of less than 100 °C.

摘要翻译： 用于制备具有式（I）的芳族酸的低温方法，所述方法包括使具有式（II）的芳族醛与基于气体总重量的1至100重量％的氧含量的气体反应， 在负载的第VIII族金属催化剂的存在下，在约20℃至小于100℃的温度和闪点大于95℃和/或熔点小于55℃的溶剂中，提供了 溶剂的闪点大于反应温度，其中R 1和R 2独立地选自氢和C 1 -C 8直链，支链或环状的烷基。 本发明的方法得到优异的收率的芳香酸，（i）不涉及有害氧化剂的使用; （ii）基本上不含副产物; 和（iii）在小于100℃的温度下完成。

公开(公告)号：WO2003008367A2

公开(公告)日：2003-01-30

申请号：PCT/US2002/022631

申请日：2002-07-16

申请人： NOVARTIS AG ,  GIRGIS, Michael, John ,  SHEKHAR, Ratna

发明人： GIRGIS, Michael, John ,  SHEKHAR, Ratna

IPC分类号： C07C51/00

CPC分类号： C07C51/235 ,  C07C63/04

摘要： A low temperature process for preparing an aromatic acid having formula (I), said process comprising reacting an aromatic aldehyde having formula (II) with a gas having an oxygen content of 1 to 100 weight percent, based on the total weight of the gas, at a temperature of about 20 °C to less than 100 °C in the presence of the supported Group VIII metal catalyst, and a solvent having a flash point greater than 95 °C and/or a melting point less than 55 °C, provided that the flash point of the solvent is greater than the reaction temperature, wherein R 1 and R 2 are independently selected from the group consisting of hydrogen and a C 1 -C 8 linear, branched or cyclic alkyl group. The process of the invention yields an aromatic acid in excellent yield, and (i) does not involve the use of deleterious oxidizing agents; (ii) is essentially free of by-products; and (iii) is accomplished at a temperature of less than 100 °C.

摘要翻译： 用于制备具有式（I）的芳族酸的低温方法，所述方法包括使具有式（II）的芳族醛与基于气体总重量的1至100重量％的氧含量的气体反应， 在负载的VIII族金属催化剂的存在下，在约20℃至小于100℃的温度下，并且提供闪点高于95℃和/或熔点小于55℃的溶剂，提供 溶剂的闪点大于反应温度，其中R 1和R 2独立地选自氢和C 1 -C 8直链，支链或环状的烷基。 本发明的方法得到优异的收率的芳香酸，（i）不涉及有害氧化剂的使用; （ii）基本上不含副产物; 和（iii）在小于100℃的温度下完成。