公开(公告)号：WO2008084069A1

公开(公告)日：2008-07-17

申请号：PCT/EP2008/050221

申请日：2008-01-10

Applicant: INSERM (Institut National de la Santé et de la Recherche Médicale) ,  SIEWEKE, Michael

Inventor： SIEWEKE, Michael

IPC: C12N5/06 ,  C07K14/82 ,  A61K45/00

CPC classification number: A61K35/15 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/0011 ,  A61K2035/124 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K14/82 ,  C12N5/0639 ,  C12N5/0645 ,  C12N2501/22 ,  C12N2501/60 ,  C12N2503/02 ,  G01N33/5055

Abstract: The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes, macrophages or dendritic cells; and expanding the cells in the presence of at least one cytokine or an agonist of cytokine receptor signalling.

Abstract translation: 本发明涉及用于扩增单核细胞，巨噬细胞或树突状细胞的离体方法，该方法包括抑制MafB和c-Maf在单核细胞，巨噬细胞或树突状细胞中的表达或活性; 并在细胞因子受体信号传导的至少一种细胞因子或激动剂的存在下扩增细胞。

公开(公告)号：WO2011003988A1

公开(公告)日：2011-01-13

申请号：PCT/EP2010/059843

申请日：2010-07-08

Applicant: INSERM (Institut National de la Santé et de la Recherche Médicale) ,  SIEWEKE, Michael

Inventor： SIEWEKE, Michael

IPC: C07K14/47 ,  C12N5/078 ,  A61K35/12 ,  C12N15/85 ,  C12N5/0786

CPC classification number: C12N5/0645 ,  A61K35/12 ,  C07H21/04 ,  C12N5/0634 ,  C12N5/0635 ,  C12N5/0641 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C12N15/907 ,  C12N2501/60 ,  C12N2510/00 ,  C12N2517/02

Abstract: The present invention relates to a method for inducing proliferation of functionally differentiated somatic cells comprising a step of activating expression of a Myc family gene and a KIf family gene in said cells or contacting said cells with a Myc family protein and a KIf family protein.

Abstract translation: 本发明涉及诱导功能分化体细胞增殖的方法，其包括在所述细胞中激活Myc家族基因和KIf家族基因的表达或使所述细胞与Myc家族蛋白和KIf家族蛋白接触的步骤。