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    PAN-DR BINDING POLYPEPTIDES AND USES THEREOF
    6.
    发明申请
    PAN-DR BINDING POLYPEPTIDES AND USES THEREOF 审中-公开
    泛DR结合多肽及其用途

    公开(公告)号：WO2010086294A3

    公开(公告)日：2010-11-25

    申请号：PCT/EP2010050839

    申请日：2010-01-26

    Applicant: EPIMMUNE INC ,  DEGAN FLORENCE DAL ,  NEWMAN MARK J ,  ALEXANDER JEFFERY L ,  SOUTHWOOD SCOTT

    Inventor： DEGAN FLORENCE DAL ,  NEWMAN MARK J ,  ALEXANDER JEFFERY L ,  SOUTHWOOD SCOTT

    IPC: C07K7/04 ,  C07K14/435

    CPC classification number: A61K39/39 ,  A61K2039/55516 ,  C07K7/08 ,  C07K2319/00

    Abstract: The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO : 1), wherein X1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X2 is selected from the group consisting of F, N, Y and W; X3 is selected from the group consisting of H and K, and X4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFV AAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.

    Abstract translation: 本发明提供了能够结合由几个等位基因编码的HLA II类分子的新型人工寡肽。 寡肽包括序列AX1FVAAX2TLX3AX4A（SEQ ID NO：1），其中X1选自W，F，Y，H，D，E，N，Q，I和K; X2选自F，N，Y和W; X3选自H和K，并且X4选自A，D和E，条件是寡肽序列不是AKFV AAWTLKAAA。 本发明还涉及包含寡肽，编码寡肽和较大肽的多核苷酸的较大肽，以及包含寡肽，肽或多核苷酸的组合物。 还公开了用于诱导免疫应答的方法。

    PAN-DR BINDING POLYPEPTIDES AND USES THEREOF
    7.
    发明申请
    PAN-DR BINDING POLYPEPTIDES AND USES THEREOF 审中-公开
    PAN-DR结合聚合物及其用途

    公开(公告)号：WO2010086294A2

    公开(公告)日：2010-08-05

    申请号：PCT/EP2010/050839

    申请日：2010-01-26

    Applicant: EPIMMUNE INC. ,  DEGAN, Florence Dal ,  NEWMAN, Mark J. ,  ALEXANDER, Jeffery L. ,  SOUTHWOOD, Scott

    Inventor： DEGAN, Florence Dal ,  NEWMAN, Mark J. ,  ALEXANDER, Jeffery L. ,  SOUTHWOOD, Scott

    IPC: C07K7/04 ,  C07K14/435

    CPC classification number: A61K39/39 ,  A61K2039/55516 ,  C07K7/08 ,  C07K2319/00

    Abstract: The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX 1 FVAAX 2 TLX 3 AX 4 A (SEQ ID NO : 1), wherein X 1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X 2 is selected from the group consisting of F, N, Y and W; X 3 is selected from the group consisting of H and K, and X 4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFV AAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.

    Abstract translation: 本发明提供能够结合由几个等位基因编码的HLA II类分子的新型人造寡肽。 寡肽包括序列AX1FVAAX2TLX3AX4A（SEQ ID NO：1），其中X1选自W，F，Y，H，D，E，N，Q，I和K; X2选自F，N，Y和W; X 3选自H和K，X 4选自A，D和E，条件是寡肽序列不是AKFV AAWTLKAAA。 本发明还涉及包含寡肽的较大肽，编码寡肽的多核苷酸和较大肽，以及包含寡肽，肽或多核苷酸的组合物。 还公开了诱导免疫应答的方法。

    HLA CLASS I AND II BINDING PEPTIDES AND THEIR USES
    9.
    发明申请
    HLA CLASS I AND II BINDING PEPTIDES AND THEIR USES 审中-公开
    HLA一级和二级结合肽及其用途

    公开(公告)号：WO2003040165A2

    公开(公告)日：2003-05-15

    申请号：PCT/US2001/051650

    申请日：2001-10-18

    Applicant: EPIMMUNE INC. ,  SETTE, Alessandro ,  SIDNEY, John ,  SOUTHWOOD, Scott

    Inventor： SETTE, Alessandro ,  SIDNEY, John ,  SOUTHWOOD, Scott

    IPC: C07K

    CPC classification number: A61K39/385 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/605

    Abstract: The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.

    Abstract translation: 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 所述肽可用于引发针对所需抗原的免疫应答。

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