公开(公告)号：WO2018183204A1

公开(公告)日：2018-10-04

申请号：PCT/US2018/024373

申请日：2018-03-26

Applicant: SPIROSURE, INC.

Inventor： LEARD, Ryan, R. ,  STEUERMAN, David ,  SSENYANGE, Solomon

IPC: A61B5/08 ,  G01N33/497

CPC classification number: A61B5/082 ,  A61B5/0075 ,  A61B5/097 ,  G01N33/497 ,  G01N33/98 ,  G01N2033/4975 ,  G01N2800/042

Abstract: A monitoring system is disclosed that includes features for detecting the presence of biomarkers from a gas sample, such as exhaled breath. An assembly includes a plurality of sensors to detect biomarkers present in exhaled breath that are associated with hyperglycemia. The biomarkers include, without limitation, acetone, ethanol, and methyl nitrate.

公开(公告)号：WO2018160733A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/020277

申请日：2018-02-28

Applicant: SPIROSURE, INC. ,  NGK SPARK PLUG CO., LTD.

Inventor： YOKOYAMA, Takahiro ,  ITO, Tatsunori ,  NISHIYAMA, Hiroyuki ,  TAKAKURA, Masahiro ,  AOYAMA, Shigeya ,  LEARD, Ryan R. ,  ANVAR, David ,  SSENYANGE, Solomon

IPC: A61B5/08 ,  A61B5/097 ,  G01N33/00 ,  G01N33/497

Abstract: A measurement system is disclosed that includes features for detecting the presence of nitric oxide from a gas sample, such as exhaled breath. The measurement system includes an assembly that introduces one or more reducing gases into a reactor-sensor assembly to help stabilize the sensor signal response and improve the performance of the assembly over time. Suitable reducing gases include hydrogen gas (H 2 ), carbon dioxide (CO), benzaldehyde, bisphenol A, and other similar compounds. The reducing gas may be introduced directly from one or more surrounding gases or through tubing or inline piping. The reducing gas may be generated from the liquid or solid forms.

公开(公告)号：WO2018098483A1

公开(公告)日：2018-05-31

申请号：PCT/US2017/063483

申请日：2017-11-28

Applicant: SPIROSURE, INC.

Inventor： LEARD, Ryan ,  OMWEG, Greg ,  AWABDY, Brian

IPC: A61B5/097 ,  A61B5/08

CPC classification number: A61B5/087 ,  A61B5/082 ,  A61B5/091 ,  A61B5/097 ,  A61B2560/0443 ,  G01N33/0073 ,  G01N33/497

Abstract: A device for use with a respiratory monitor is disclosed that includes features for collecting and guiding a breath gas sample from a user. The device includes a breath intake structure connected to a handheld body structure. The breath intake structure may include one or more permeable membranes to filter particular substances, such as bacteria, viruses, and microbes, from the breath gas sample before it proceeds through the body structure. The device further includes one or more pre-conditioning elements that pretreats the breath gas sample before it enters a respiratory monitor. In some embodiments, the device may include a mouthpiece and body that are used to collect and guide a breath gas sample to a nitric oxide detection device. Moisture is removed from the breath gas sample using a desiccant loaded into a pre-conditioning cartridge. The mouthpiece may be removably connected to the body and disposable. Interchangeable pre-conditioning cartridges may allow use of different cartridges and different pre-conditioning materials with the device.

公开(公告)号：WO2018222803A1

公开(公告)日：2018-12-06

申请号：PCT/US2018/035285

申请日：2018-05-31

Applicant: NGK SPARK PLUG CO., LTD. ,  SPIROSURE, INC.

Inventor： MORITA, Kazuto ,  NISHIYAMA, Hiroyuki ,  YOKOYAMA, Takahiro ,  TAKAKURA, Masahiro ,  ITO, Tatsunori ,  USHIDA, Takahisa ,  SSENYANGE, Solomon ,  AWABDY, Brian ,  LEARD, Ryan

IPC: A61B5/097 ,  G01N27/407

CPC classification number: G01N33/0013 ,  G01N33/0037

Abstract: A gas detection apparatus for detecting the concentration of a first gas component contained in a gas under measurement includes a gas conversion section for converting the first gas component to a second gas component, a gas detection section whose electrical characteristics change with a change in the concentration of the second gas component when the gas detection section is in an activated state, and a detection state setting section. During a detection period, the detection state setting section sets the state of gas detection by the gas detection section to a detection executed state in which the gas detection section can detect the second gas component. During periods which are not the detection period, the detection state setting section sets the state of gas detection by the gas detection section to a detection suspended state in which the gas detection section does not detect the second gas component.

公开(公告)号：WO2018160606A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/020066

申请日：2018-02-28

Applicant: NGK SPARK PLUG CO., LTD. ,  SPIROSURE, INC.

Inventor： OMORI, Koji ,  TAKAKURA, Masahiro ,  SSENYANGE, Solomon ,  LEARD, Ryan

IPC: G01N27/407 ,  G01N27/419 ,  G01N27/36

CPC classification number: G01N27/4077 ,  G01N27/4074 ,  G01N27/4075

Abstract: A mixed-potential-type sensor for measuring the concentration of nitrogen oxide contained in a gas under measurement including a solid electrolyte layer having oxygen-ion conductivity, and a pair of porous electrodes formed thereon. One electrode is covered with a first layer containing tungsten oxide as a main component. The other electrode is covered with a gas impermeable second layer. The second layer is in contact with the other electrode without intervention of the tungsten oxide component. The solid electrolyte layer is porous and allows the gas under measurement to permeate from an externally exposed surface of the solid electrolyte layer to the other electrode. The concentration of the nitrogen oxide is detected from a potential difference developed between the electrodes.

公开(公告)号：WO2018017502A1

公开(公告)日：2018-01-25

申请号：PCT/US2017/042459

申请日：2017-07-17

Applicant: SPIROSURE, INC.

Inventor： FURUSAKI, Keizo ,  SSENYANGE, Solomon ,  LEARD, Ryan, R.

IPC: A61B5/083 ,  A61B5/097 ,  A61B5/08

CPC classification number: A61B5/083 ,  A61B5/082 ,  A61B5/097 ,  G01N2033/4975

Abstract: A respiratory monitor is disclosed that includes features for conducting multiple pulmonary function tests in a single device and for detecting the presence of nitric oxide in exhaled breath. The respiratory monitor includes one or more reactor and sensor assemblies. Also described is a mouthpiece that allows for separate inhalation and exhalation pathways and for filtering inhaled and exhaled breath for predetermined species prior to exhalation into the respiratory monitor. The monitor further allows for wired, wireless and network connectivity and for cloud-based systems for communicating and correlating pulmonary data as well as relevant environmental data and displaying the data for use by patients and health care professionals.

Abstract translation: 公开了一种呼吸监测器，其包括用于在单个装置中进行多个肺功能测试和用于检测呼出气中一氧化氮的存在的特征。 呼吸监测器包括一个或多个反应器和传感器组件。 还描述了一种喉舌，其允许单独的吸气和呼气途径以及在呼入呼吸监测器之前过滤预定物种的吸气和呼气。 该显示器进一步允许有线，无线和网络连接以及基于云的系统，用于传达和关联肺部数据以及相关的环境数据并显示供患者和医疗保健专业人员使用的数据。

公开(公告)号：WO2018175108A1

公开(公告)日：2018-09-27

申请号：PCT/US2018/021361

申请日：2018-03-07

Applicant: NGK SPARK PLUG CO., LTD. ,  SPIROSURE, INC.

Inventor： KUMAZAKI, Takayuki ,  UEKI, Masatoshi ,  SHICHIDA, Takafumi ,  NISHIO, Kenji ,  INOUE, Tsuyoshi ,  AOYAMA, Shigeya ,  SSENYANGE, Solomon ,  LEARD, Ryan

IPC: A61B5/097 ,  G01N33/497

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/097 ,  G01N33/0037 ,  G01N2033/4975 ,  Y02A50/245

Abstract: A gas sensor including an adjustment unit having a conversion element for converting a gas component contained in exhaled breath introduced into a first chamber to a particular component, a sensor unit having a second chamber and including a detection element, a ceramic wiring board electrically connected to the detection element, and a single heater for heating the conversion element and the detection element. The ceramic wiring board has an opening, and a ceramic thin plate is stacked on the ceramic wiring board to cover the opening. The ceramic thin plate partially constitutes the adjustment unit and the sensor unit and separates the first chamber and the second chamber from each other. The adjustment unit, the sensor unit, and the heater are integrated in such a manner that the adjustment unit and the sensor unit are thermally coupled through the ceramic thin plate.

公开(公告)号：WO2018164891A1

公开(公告)日：2018-09-13

申请号：PCT/US2018/020065

申请日：2018-02-28

Applicant: NGK SPARK PLUG CO., LTD. ,  SPIROSURE, INC.

Inventor： OMORI, Koji ,  ITO, Tatsunori ,  NISHIYAMA, Hiroyuki ,  TAKAKURA, Masahiro ,  SSENYANGE, Solomon ,  LEARD, Ryan

IPC: G01N27/407 ,  A61B5/087 ,  G01N33/497

CPC classification number: G01N27/4075 ,  G01N27/4067 ,  G01N27/407 ,  G01N33/0013 ,  G01N33/0037 ,  G01N33/497

Abstract: A gas sensor including a conversion section for converting NO contained in a gas under measurement to NO 2 , and a detection section for detecting NO 2 concentration in the gas under measurement after having passed through the conversion section. The conversion section includes a substrate portion which defines a flow passage for the gas under measurement, and a porous catalyst layer disposed on a surface of the substrate portion which converts NO to NO 2 . The flow passage has a hollow space in which the catalyst layer is not present and through which the gas under measurement flows. The catalyst layer has a thickness of 4 to 300 µm as measured between the substrate portion and an outermost surface of the catalyst layer, the outermost surface being exposed to the hollow space.

公开(公告)号：WO2018160620A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/020092

申请日：2018-02-28

Applicant: NGK SPARK PLUG CO., LTD. ,  SPIROSURE, INC.

Inventor： NAKAGAWA, Shinichi ,  ITO, Tatsunori ,  NISHIYAMA, Hiroyuki ,  TAKAKURA, Masahiro ,  UEKI, Masatoshi ,  SSENYANGE, Solomon ,  LEARD, Ryan

IPC: A61B5/08

CPC classification number: A61B5/082 ,  A61B5/097 ,  G01N33/497 ,  G01N2033/4975

Abstract: A breath sensor including a main body into which breath can be introduced, a conversion section for converting a gas component contained in the breath to a specific component, and a sensing section for detecting the specific component. The sensing section constitutes a first unit including an integrated detection element and a first heater. The conversion section constitutes a second unit including an integrated catalyst and a second heater. The first unit and the second unit are disposed inside the main body so as to be separated from each other with a gap therebetween, or are in contact with each other via a heat insulating member. The first unit and second unit are in communication with each other through a pipe that allows the breath to pass therethrough, and the pipe is partially bent.

公开(公告)号：WO2019018121A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/040508

申请日：2018-06-30

Applicant: SPIROSURE, INC.

Inventor： SSENYANGE, Solomon ,  ANVAR, David ,  AWABDY, Brian ,  SMITH, Todd ,  LEARD, Ryan

IPC: A61B5/08 ,  A61B5/097

Abstract: A breath collection and storage apparatus is disclosed for collecting and storing samples of exhaled breath for later analysis of nitric oxide contained in collected breath samples. The described apparatus provides for inhaling air into the lungs via a one-way air inflow portal through an airflow chamber via an inhalation/exhalation portal. Air inhaled into the lungs is then expelled back into the airflow chamber via the inhalation/exhalation portal and flowed into a breath storage vessel. A flow meter monitor, such as a flow meter or pressure gauge can be employed to monitor and control the rate of flow of the exhaled breath. A three-way valve can be incorporated into the air outflow portal to selectively permit discharge of exhaled breath to the outside or into the breath storage vessel. If desired, a programmable controller in electrical connection with the flow meter and three-way valve can be employed to maneuver the three-way valve to discharge and collection positions to allow for collecting and storing preselected portions of the exhaled breath. In addition, a flow rate restriction mechanism can be employed to automatically control the flow rate of exhaled air (breath) through the airflow chamber.