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1.发明申请
公开(公告)号：WO2017037300A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070893
申请日：2016-09-05
发明人： LINDMARK, Bertil , OOI, Lisa
CPC分类号： A61K31/51
摘要： The present disclosure provides a method of treating a patient with refractory or resistant cancer by administering a therapeutically effective amount of a compound of formula (I), such as Varlitinib, or an enantiomer thereof or a pharmaceutically acceptable salt of any one of the same. Also provided is a compound of formula (I) for use in the treatment of resistant or refractory cancer and use of a compound of formula (I) for the manufacture of a medicament for the treatment of resistant or refractory cancer.
摘要翻译： 本公开提供了通过施用治疗有效量的式（I）化合物，例如Varlitinib或其对映异构体或其任何一种的药学上可接受的盐来治疗患有难治性或耐药性癌症的患者的方法。 还提供了用于治疗耐药性或难治性癌症的式（I）化合物和式（I）化合物在制备用于治疗耐药性或难治性癌症的药物中的用途。
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公开(公告)号：WO2017037299A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070890
申请日：2016-09-05
发明人： LINDMARK, Bertil , MCHALE, Mark Thomas , OOI, Lisa
CPC分类号： A61K31/51
摘要： The present disclosure provides a method of treating a biliary duct cancer, such as cholangiocarcinoma, by administering a therapeutically effective amount of a compound of formula (I), in particular Varlitinib, an enantiomer thereof or a pharmaceutically acceptable salt of any one of the same.
摘要翻译： 本公开提供了治疗胆管癌如胆管癌的方法，其通过施用治疗有效量的式（I）化合物，特别是Varlitinib，其对映体或其任何相同的药学上可接受的盐 。
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3.发明申请COMBINATION OF A DHODH INHIBITOR AND A HER INHIBITOR FOR USE IN THE TREATMENT OF CANCER 审中-公开一种DHODH抑制剂和一种用于治疗癌症的HER抑制剂的组合
公开(公告)号：WO2017037292A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070874
申请日：2016-09-05
发明人： LINDMARK, Bertil , MCHALE, Mark Thomas , OOI, Lisa
CPC分类号： A61K31/51
摘要： The present disclosure provides method of treating a cancer patient comprising administering a therapeutically effect amount of a DHODH inhibitor and a therapeutically effective amount of an inhibitor of a HER receptor, for example an inhibitor of at least HER2. Also provided is a combination therapy comprising a HER inhibitor and a DHODH inhibitor for use in the treatment of cancer and use of a HER inhibitor and a DHODH inhibitor in the manufacture of a combination therapy for the treatment of cancer.
摘要翻译： 本公开提供了治疗癌症患者的方法，包括施用治疗有效量的DHODH抑制剂和治疗有效量的HER受体抑制剂，例如至少HER2的抑制剂。 还提供了包含用于治疗癌症的HER抑制剂和DHODH抑制剂的组合疗法，以及在制备用于治疗癌症的组合疗法中使用HER抑制剂和DHODH抑制剂。
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4.发明申请A COMBINATION THERAPY COMPRISING VARLITINIB AND AN ANTICANCER AGENT 审中-公开包含VARLITINIB和ANTICANCER代理的组合治疗
公开(公告)号：WO2017037298A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070888
申请日：2016-09-05
发明人： LINDMARK, Bertil , OOI, Lisa
CPC分类号： A61K31/51
摘要： In one aspect the present disclosure provides a method of sensitizing a cancer patient to chemotherapy by administering a combination therapy comprising; a) a therapeutically effective amount of a compound of formula (I) an enantiomer thereof or a pharmaceutically acceptable salts of any one of the same, and b) a chemotherapeutic agent or a combination of chemotherapeutic agents.
摘要翻译： 一方面，本公开提供了一种通过施用组合疗法使癌症患者对化学疗法敏感的方法，包括： a）治疗有效量的式（I）化合物其对映体或其任何一种的药学上可接受的盐，和b）化学治疗剂或化学治疗剂的组合。
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