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1.发明申请HIGH THROUGHPUT SCREENING OF SOLUBILITY FOR COMPOUNDS IN DIFFERENT EXCIPIENTS 审中-公开化合物在不同成分中的溶解性的高通量筛选
公开(公告)号：WO2006083651A3
公开(公告)日：2006-09-21
申请号：PCT/US2006002665
申请日：2006-01-25
Applicant: DECODE BIOSTRUCTURES INC , DUAN MATT , MCDERMOTT CHARLES , HOFFMAN AARON , STEWART LANSING J , THORSTEINSSON THORSTEINN , O'FEE BOB , ZEMBOWER DAVID
Inventor： DUAN MATT , MCDERMOTT CHARLES , HOFFMAN AARON , STEWART LANSING J , THORSTEINSSON THORSTEINN , O'FEE BOB , ZEMBOWER DAVID
CPC classification number: G01N33/15
Abstract: Methods for screening compounds for their solubility and their solution stability in a variety of diverse formulations and sets of diverse formulations useful for screening compounds for their solubility and their solution stability.
Abstract translation: 筛选化合物的溶解度及其溶液稳定性的方法可用于各种各样的制剂和多种制剂的组合，用于筛选化合物的溶解度及其溶液稳定性。
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公开(公告)号：WO2010147958A3
公开(公告)日：2011-03-31
申请号：PCT/US2010038633
申请日：2010-06-15
Applicant: EMERALD BIOSTRUCTURES INC , GERDTS CORY , LOVATT ANDREW M , CRISP PAUL M , NOLLERT-VON SPECHT PETER , STEWART LANSING J
Inventor： GERDTS CORY , LOVATT ANDREW M , CRISP PAUL M , NOLLERT-VON SPECHT PETER , STEWART LANSING J
CPC classification number: G01N35/0099 , B01L2200/027 , G01N2035/00158
Abstract: A robot is described for automatically performing microfluidic experiments that are often complex and repetitive. The robot includes a system for initiating the communication of off-chip fluids, such as fluorocarbons, and off-chip materials, such as proteins. The communication of off-chip fluids and off-chip materials is further guided to a microfluidics device vis-a-vis a Z-head robot, an XY plane robot, and an interface assembly that creates a fluid-tight joint for communicating the off-chip fluids and off-chip materials into the microfluidics device for conduction of microfluidics experiments.
Abstract translation: 描述了一种机器人，用于自动执行通常是复杂和重复的微流体实验。 机器人包括用于启动片外流体（例如碳氟化合物）和片外材料（例如蛋白质）的通信的系统。 与Z头机器人，XY平面机器人和界面组件相比，片外流体和片外材料的通信被进一步引导到微流体装置，该界面组件产生用于传递关闭的流体密封接头 将芯片流体和片外材料转化成用于微流体实验的微流体装置。
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Patent Agency Ranking
公开(公告)号：WO2009152520A3
公开(公告)日：2010-02-18
申请号：PCT/US2009047414
申请日：2009-06-15
Applicant: DECODE BIOSTRUCTURES INC , GERDTS CORY , ELLIOTT MARK , NOLLERT-VON-SPECHT PETER , STEWART LANSING J
Inventor： GERDTS CORY , ELLIOTT MARK , NOLLERT-VON-SPECHT PETER , STEWART LANSING J
IPC: C30B7/00
CPC classification number: B01D9/00 , B01F5/0256 , B01F13/0059 , B01L3/06 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0877 , C07K1/306 , C30B7/00 , C30B29/58
Abstract: A nanovolume microcapillary crystallization system allows nanoliter-volume screening of crystallization conditions in a crystal card that allows crystals to either be removed for traditional cryoprotection or in situ X-ray diffraction studies on protein crystals that grow within. The system integrates formulation of crystallization cocktails with preparation of the crystallization experiments. The system allows the researcher to select either gradient screening in crystallization experiments for efficient exploration of crystallization phase space or a combination of sparse matrix with gradient screening to execute one comprehensive hybrid crystallization trial.
Abstract translation: 纳米级微毛细管结晶系统允许纳米级体积筛选晶体卡中的结晶条件，其允许将晶体除去用于传统的冷冻保护或在其内生长的蛋白质晶体的原位X射线衍射研究。 该系统将结晶鸡尾酒配方与结晶实验的准备相结合。 该系统允许研究者选择结晶实验中的梯度筛选，以有效探索结晶相空间，或者通过梯度筛选稀释基质的组合进行一次综合混合结晶试验。
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公开(公告)号：WO2006083651A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002665
申请日：2006-01-25
Applicant: DECODE BIOSTRUCTURES, INC. , DUAN, Matt , MCDERMOTT, Charles , HOFFMAN, Aaron , STEWART, Lansing, J , THORSTEINSSON, Thorsteinn , O'FEE, Bob , ZEMBOWER, David
Inventor： DUAN, Matt , MCDERMOTT, Charles , HOFFMAN, Aaron , STEWART, Lansing, J , THORSTEINSSON, Thorsteinn , O'FEE, Bob , ZEMBOWER, David
CPC classification number: G01N33/15
Abstract: Methods for screening compounds for their solubility and their solution stability in a variety of diverse formulations and sets of diverse formulations useful for screening compounds for their solubility and their solution stability.
Abstract translation: 筛选化合物的溶解度及其溶液稳定性的方法可用于各种不同配方和多种制剂的组合，用于筛选化合物的溶解度及其溶液稳定性。
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公开(公告)号：WO02083938A3
公开(公告)日：2003-07-17
申请号：PCT/US0211552
申请日：2002-04-11
Applicant: EMERALD BIOSTRUCTURES INC , STEWART LANSING J
Inventor： STEWART LANSING J
IPC: B01D9/02 , C12Q1/68 , G01N31/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G06F19/00 , C12N9/90 , G01N33/542
CPC classification number: G01N33/54313 , G01N33/68
Abstract: This invention relates to crystallization based assays for identifying ligands that bind to a macromolecule.
Abstract translation: 本发明涉及用于鉴定结合大分子的配体的基于结晶的测定法。
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公开(公告)号：WO2010147958A2
公开(公告)日：2010-12-23
申请号：PCT/US2010/038633
申请日：2010-06-15
Applicant: EMERALD BIOSTRUCTURES, INC. , GERDTS, Cory , LOVATT, Andrew, M. , CRISP, Paul, M. , NOLLERT-VON SPECHT, Peter , STEWART, Lansing, J.
Inventor： GERDTS, Cory , LOVATT, Andrew, M. , CRISP, Paul, M. , NOLLERT-VON SPECHT, Peter , STEWART, Lansing, J.
CPC classification number: G01N35/0099 , B01L2200/027 , G01N2035/00158
Abstract: A robot is described for automatically performing microfluidic experiments that are often complex and repetitive. The robot includes a system for initiating the communication of off-chip fluids, such as fluorocarbons, and off-chip materials, such as proteins. The communication of off-chip fluids and off-chip materials is further guided to a microfluidics device vis-a-vis a Z-head robot, an XY plane robot, and an interface assembly that creates a fluid-tight joint for communicating the off-chip fluids and off-chip materials into the microfluidics device for conduction of microfluidics experiments.
Abstract translation: 描述了一种机器人，用于自动执行微流体实验，这些实验往往是复杂和重复的。 机器人包括用于启动片外流体（例如碳氟化合物）和片外材料（例如蛋白质）的通信的系统。 与Z头机器人，XY平面机器人和接口组件相比，片外流体和片外材料的通信被进一步引导到微流体装置，该界面组件产生用于传递关闭的流体密封接头 将芯片流体和片外材料转入微流体装置中用于微流体实验的传导。
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公开(公告)号：WO2009152520A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/047414
申请日：2009-06-15
Applicant: DECODE BIOSTRUCTURES, INC. , GERDTS, Cory , ELLIOTT, Mark , NOLLERT-VON-SPECHT, Peter , STEWART, Lansing, J.
Inventor： GERDTS, Cory , ELLIOTT, Mark , NOLLERT-VON-SPECHT, Peter , STEWART, Lansing, J.
IPC: B01L3/06
CPC classification number: B01D9/00 , B01F5/0256 , B01F13/0059 , B01L3/06 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0877 , C07K1/306 , C30B7/00 , C30B29/58
Abstract: A nanovolume microcapillary crystallization system allows nanoliter-volume screening of crystallization conditions in a crystal card that allows crystals to either be removed for traditional cryoprotection or in situ X-ray diffraction studies on protein crystals that grow within. The system integrates formulation of crystallization cocktails with preparation of the crystallization experiments. The system allows the researcher to select either gradient screening in crystallization experiments for efficient exploration of crystallization phase space or a combination of sparse matrix with gradient screening to execute one comprehensive hybrid crystallization trial.
Abstract translation: 纳米级微毛细管结晶系统允许纳米级体积筛选晶体卡中的结晶条件，其允许将晶体除去用于传统的冷冻保护或在其内生长的蛋白质晶体的原位X射线衍射研究。 该系统将结晶鸡尾酒配方与结晶实验的准备相结合。 该系统允许研究者选择结晶实验中的梯度筛选，以有效探索结晶相空间，或者通过梯度筛选稀释基质的组合进行一次综合混合结晶试验。
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