公开(公告)号：WO2005011638A3

公开(公告)日：2005-02-10

申请号：PCT/CZ2004/000045

申请日：2004-08-05

Applicant: ZENTIVA, A. S. ,  SEBEK, Pavel ,  PROKOPOVA, Alena ,  SVOBODA, Eduard ,  RADL, Stanislav ,  STACH, Jan ,  SVOBODA, Martin ,  KOVACIK, Andrej ,  DANKO, Adrian ,  PETRO, Roman ,  STRIZINEC, Miroslav

Inventor： SEBEK, Pavel ,  PROKOPOVA, Alena ,  SVOBODA, Eduard ,  RADL, Stanislav ,  STACH, Jan ,  SVOBODA, Martin ,  KOVACIK, Andrej ,  DANKO, Adrian ,  PETRO, Roman ,  STRIZINEC, Miroslav

IPC: A61K9/20

Abstract: Stabilization of the pharmaceutical active solid substance atorvastatin alone or in a mixture with other solid substances embedded in a gaseous mixture is carried out in such a manner that in the surrounding gaseous mixture a partial pressure of oxygen of at most 2 kPa, preferably less than 1 kPa, more preferably less than 0.4 kPa is maintained. The corresponding partial pressure is achieved either by use of oxygen absorbers, by packaging under a pressure of 0.3 - 10 kPa, or by packaging under a slight overpressure of an inert gas, preferably nitrogen, the gas being introduced, by means of nozzles, into the cavities, optionally also into the space of the press roller and of the wiper station.

公开(公告)号：WO2005011638A2

公开(公告)日：2005-02-10

申请号：PCT/CZ2004000045

申请日：2004-08-05

Applicant: ZENTIVA AS ,  SEBEK PAVEL ,  PROKOPOVA ALENA ,  SVOBODA EDUARD ,  RADL STANISLAV ,  STACH JAN ,  SVOBODA MARTIN ,  KOVACIK ANDREJ ,  DANKO ADRIAN ,  PETRO ROMAN ,  STRIZINEC MIROSLAV

Inventor： SEBEK PAVEL ,  PROKOPOVA ALENA ,  SVOBODA EDUARD ,  RADL STANISLAV ,  STACH JAN ,  SVOBODA MARTIN ,  KOVACIK ANDREJ ,  DANKO ADRIAN ,  PETRO ROMAN ,  STRIZINEC MIROSLAV

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/40

CPC classification number: A61K31/40 ,  A61K9/2054 ,  A61K9/2866

Abstract: Stabilization of the pharmaceutical active solid substance atorvastatin alone or in a mixture with other solid substances embedded in a gaseous mixture is carried out in such a manner that in the surrounding gaseous mixture a partial pressure of oxygen of at most 2 kPa, preferably less than 1 kPa, more preferably less than 0.4 kPa is maintained. The corresponding partial pressure is achieved either by use of oxygen absorbers, by packaging under a pressure of 0.3 - 10 kPa, or by packaging under a slight overpressure of an inert gas, preferably nitrogen, the gas being introduced, by means of nozzles, into the cavities, optionally also into the space of the press roller and of the wiper station.

Abstract translation: 药物活性固体物质阿托伐他汀单独或与包埋在气体混合物中的其它固体物质的混合物中的稳定化以这样的方式进行，即在周围的气体混合物中氧分压至多2kPa，优选小于1 kPa，更优选小于0.4kPa。 通过使用氧气吸收器，通过在0.3-10kPa的压力下包装，或者通过在稍微超压的惰性气体，优选氮气下包装来实现相应的分压，通过喷嘴将气体引入 腔体，可选地也进入压辊和擦拭器站的空间中。