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1.发明申请ANTIGEN BINDING MOLECULES HAVING MODIFIED FC REGIONS AND ALTERED BINDING TO FC RECEPTORS 审中-公开具有修饰的FC区的抗原结合分子和对FC受体的改变结合
公开(公告)号：WO2007039818A2
公开(公告)日：2007-04-12
申请号：PCT/IB2006/002888
申请日：2006-05-09
Applicant: GLYCART BIOTECHNOLOGY AG , STUART, Fiona , UMANA, Pablo , SONDERMANN, Peter , FERRARA KOLLER, Claudia , BRUNKER, Peter
Inventor： STUART, Fiona , UMANA, Pablo , SONDERMANN, Peter , FERRARA KOLLER, Claudia , BRUNKER, Peter
CPC classification number: C07K16/2863 , C07K16/2803 , C07K2317/34 , C07K2317/41
Abstract: The present invention is directed to antigen binding molecules, including antibodies, comprising a Fc region having one or more amino acid modifications, wherein the antigen binding molecule exhibits altered binding to one or more Fc receptors as a result of the modification(s). The invention is further directed to polynucleotides and vectors encoding such antigen binding molecules, to host cells comprising the same, to methods for making the antigen binding molecules of the invention, and to their use in the treatment of various diseases and disorders, e.g., cancers.
Abstract translation: 本发明涉及抗原结合分子，包括抗体，其包含具有一个或多个氨基酸修饰的Fc区，其中抗原结合分子显示出改变的与一种或多种Fc受体的结合，结果 的修改。 本发明还涉及编码此类抗原结合分子的多核苷酸和载体，包含其的宿主细胞，制备本发明的抗原结合分子的方法，以及它们在治疗各种疾病和病症中的用途，例如癌症
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2.发明申请ANTIGEN BINDING MOLECULES HAVING MODIFIED FC REGIONS AND ALTERED BINDING TO FC RECEPTORS 审中-公开具有修饰的FC区的抗原结合分子和对FC受体的改变结合
公开(公告)号：WO2007039818A3
公开(公告)日：2007-08-30
申请号：PCT/IB2006002888
申请日：2006-05-09
Applicant: GLYCART BIOTECHNOLOGY AG , STUART FIONA , UMANA PABLO , SONDERMANN PETER , FERRARA KOLLER CLAUDIA , BRUNKER PETER
Inventor： STUART FIONA , UMANA PABLO , SONDERMANN PETER , FERRARA KOLLER CLAUDIA , BRUNKER PETER
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/2803 , C07K2317/34 , C07K2317/41
Abstract: The present invention is directed to antigen binding molecules, including antibodies, comprising a Fc region having one or more amino acid modifications, wherein the antigen binding molecule exhibits altered binding to one or more Fc receptors as a result of the modification(s). The invention is further directed to polynucleotides and vectors encoding such antigen binding molecules, to host cells comprising the same, to methods for making the antigen binding molecules of the invention, and to their use in the treatment of various diseases and disorders, e.g., cancers.
Abstract translation: 本发明涉及抗原结合分子，包括抗体，其包含具有一个或多个氨基酸修饰的Fc区，其中所述抗原结合分子由于所述修饰而表现出对一个或多个Fc受体的改变的结合。 本发明还涉及编码此类抗原结合分子的多核苷酸和载体，包含其的宿主细胞，制备本发明的抗原结合分子的方法，以及它们在治疗各种疾病和病症中的用途，例如癌症 。
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3.发明申请ANTIGEN BINDING MOLECULES HAVING MODIFIED FC REGIONS AND ALTERED BINDING TO FC RECEPTORS 审中-公开具有改性FC区的抗原结合分子和与FC受体的改变的结合
公开(公告)号：WO2007039818A8
公开(公告)日：2007-11-22
申请号：PCT/IB2006002888
申请日：2006-05-09
Applicant: GLYCART BIOTECHNOLOGY AG , SONDERMANN PETER , FERRARA KOLLER CLAUDIA , BRUNKER PETER , STUART FIONA , UMANA PABLO
Inventor： SONDERMANN PETER , FERRARA KOLLER CLAUDIA , BRUNKER PETER , STUART FIONA , UMANA PABLO
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/2803 , C07K2317/34 , C07K2317/41
Abstract: The present invention is directed to antigen binding molecules, including antibodies, comprising a Fc region having one or more amino acid modifications, wherein the antigen binding molecule exhibits altered binding to one or more Fc receptors as a result of the modification(s). The invention is further directed to polynucleotides and vectors encoding such antigen binding molecules, to host cells comprising the same, to methods for making the antigen binding molecules of the invention, and to their use in the treatment of various diseases and disorders, e.g., cancers.
Abstract translation: 本发明涉及包含具有一个或多个氨基酸修饰的Fc区的抗体结合分子，其中抗原结合分子作为修饰的结果表现出与一个或多个Fc受体的结合改变。 本发明进一步涉及编码这种抗原结合分子的多核苷酸和载体，包含其的宿主细胞，用于制备本发明的抗原结合分子的方法及其在治疗各种疾病和病症例如癌症中的用途 。
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