公开(公告)号：WO2004078922A3

公开(公告)日：2006-12-21

申请号：PCT/US2004005896

申请日：2004-02-27

Applicant: ISIS PHARMACEUTICALS INC ,  TACHAS GEORGE ,  DOBIE KENNETH ,  JAIN RAVI ,  BELYEA CHRISTOPHER ,  HEFFERNAN MARK

Inventor： TACHAS GEORGE ,  DOBIE KENNETH ,  JAIN RAVI ,  BELYEA CHRISTOPHER ,  HEFFERNAN MARK

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7088 ,  A61K48/00 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/72 ,  C12N20060101 ,  C12N5/00 ,  C12N9/10 ,  C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1138 ,  C07K14/72 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y10T436/143333 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

Abstract translation: 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。

公开(公告)号：WO2004078922A2

公开(公告)日：2004-09-16

申请号：PCT/US2004/005896

申请日：2004-02-27

Applicant: ISIS PHARMACEUTICALS, INC. ,  TACHAS, George ,  DOBIE, Kenneth

Inventor： TACHAS, George ,  DOBIE, Kenneth

IPC: C12N

CPC classification number: C12N15/1138 ,  C07K14/72 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y10T436/143333 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.

Abstract translation: 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含靶向编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。

公开(公告)号：WO2012034194A1

公开(公告)日：2012-03-22

申请号：PCT/AU2011/001205

申请日：2011-09-19

Applicant: ANTISENSE THERAPEUTICS LTD ,  TACHAS, George

Inventor： TACHAS, George

IPC: A61K31/7125 ,  A61P43/00 ,  C07H21/00

CPC classification number: C12N15/1138 ,  A61K31/7105 ,  A61K31/7125 ,  A61K35/28 ,  A61K38/193 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/344 ,  C12N2310/346 ,  C12N2310/3525

Abstract: The present disclosure relates to methods for mobilizing stem and/or progenitor cells which are VLA-4 positive to the peripheral blood of a subject or from a tissue. The method comprises administering to the subject or tissue an effective amount of an antisense compound to VLA-4.

Abstract translation: 本公开涉及用于动员对受试者或来自组织的外周血是VLA-4阳性的干细胞和/或祖细胞的方法。 该方法包括向受试者或组织施用有效量的对VLA-4的反义化合物。

公开(公告)号：WO2006086821A1

公开(公告)日：2006-08-24

申请号：PCT/AU2005/001634

申请日：2005-10-20

Applicant: ANTISENSE THERAPEUTICS LTD ,  TACHAS, George ,  KARRAS, James, G. ,  GREGORY, Susan ,  CROSBY, Jeffrey, R. ,  DOBIE, Kenneth, W. ,  BENNETT, C., Frank

Inventor： TACHAS, George ,  KARRAS, James, G. ,  GREGORY, Susan ,  CROSBY, Jeffrey, R. ,  DOBIE, Kenneth, W. ,  BENNETT, C., Frank

IPC: A61K31/711 ,  A61P11/00

CPC classification number: A61K31/711 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 µg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.

Abstract translation: 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞增多症，白细胞或过度产生粘液和/或与整联蛋白a4表达有关的呼吸系统疾病或病症的动物的方法，包括向动物施用包含 。 0.001至1000μg/ kg体重的靶向编码整联蛋白a4的核酸分子的反义化合物的动物。