公开(公告)号：WO2023087105A1

公开(公告)日：2023-05-25

申请号：PCT/CA2022/051694

申请日：2022-11-16

Applicant: TELO GENOMICS HOLDINGS CORP.

Inventor： MAI, Sabine ,  LOUIS, Sherif ,  KNECHT, Hans

IPC: C12Q1/6809 ,  C12Q1/6841 ,  G16B15/10 ,  G16B25/00

Abstract: Provided are methods for prognosing a clinical outcome in a subject or diagnosing the subject with high-risk or stable smoldering multiple myeloma (SMM), comprising determining a 3D telomeres organization signature of a test sample from the subject, the test sample comprising plasma cells, applying a classification model to the 3D telomeres organization signature to obtain an output classification that is indicative of the clinical outcome or diagnosis of the subject. Also provided are methods for treating a subject with high-risk or stable SMM.