公开(公告)号：WO2018035496A1

公开(公告)日：2018-02-22

申请号：PCT/US2017/047675

申请日：2017-08-18

Applicant: THE REASEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： GONG, Bing

IPC: A61K38/04 ,  A61K47/30 ,  C07K14/60

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07D259/00 ,  C07K14/60 ,  C08L77/02 ,  C08L77/04 ,  C08L2203/02

Abstract: Provided are macrocyclic compounds having one or more transmembrane segment-thermoresponsive segment moiety. Also provided are dimers comprising two macrocyclic units, which have one or more transmembrane segment-thermoresponsive segment moiety, joined by one or more crosslinking moieties. The macrocyclic compounds and macrocyclic units have a macrocyclic backbone comprise alternating alpha amino acid and meta -aminobenzoic acid moieties. The macrocyclic compounds and dimers can be used to deliver a cargo (e.g., cell-interacting agents such as, for example, drugs and cryoprotectants) to, for example, an organ, tissue, or an individual, A cargo may be encapsulated in lipid vesicles.

Abstract translation: 所提供的是具有一个或多个跨膜片段 - 热响应片段部分的大环化合物。 还提供了包含两个大环单元的二聚体，其具有一个或多个由一个或多个交联部分连接的跨膜片段 - 热响应片段部分。 大环化合物和大环单元具有包含交替的α氨基酸和间 - 氨基苯甲酸部分的大环骨架。 大环化合物和二聚体可用于将货物（例如细胞相互作用剂，例如药物和冷冻保护剂）递送至例如器官，组织或个体。可将货物封装在脂质 囊泡。