公开(公告)号：WO2006065861A2

公开(公告)日：2006-06-22

申请号：PCT/US2005/045169

申请日：2005-12-12

Applicant: AMGEN INC ,  TREUHEIT, Michael, J. ,  DHARMAVARAM, Vasumathi ,  PURTELL, Judith ,  ROY, Suzanne, E.

Inventor： TREUHEIT, Michael, J. ,  DHARMAVARAM, Vasumathi ,  PURTELL, Judith ,  ROY, Suzanne, E.

IPC: A61K38/18 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K9/19 ,  A61K38/1825 ,  A61K47/183 ,  A61K47/26 ,  C07K14/50

Abstract: The present invention provides long-term stable formulations of lyophilized keratinocyte growth factor and methods for making a lyophilized composition comprising keratinocyte growth factor.

Abstract translation: 本发明提供了冻干角化细胞生长因子的长期稳定制剂和制备包含角化细胞生长因子的冻干组合物的方法。

公开(公告)号：WO2006065861A3

公开(公告)日：2006-08-17

申请号：PCT/US2005045169

申请日：2005-12-12

Applicant: AMGEN INC ,  TREUHEIT MICHAEL J ,  DHARMAVARAM VASUMATHI ,  PURTELL JUDITH ,  ROY SUZANNE E

Inventor： TREUHEIT MICHAEL J ,  DHARMAVARAM VASUMATHI ,  PURTELL JUDITH ,  ROY SUZANNE E

IPC: A61K38/18 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K9/19 ,  A61K38/1825 ,  A61K47/183 ,  A61K47/26 ,  C07K14/50

Abstract: The present invention provides long-term stable formulations of lyophilized keratinocyte growth factor and methods for making a lyophilized composition comprising keratinocyte growth factor.

Abstract translation: 本发明提供了冻干角质形成细胞生长因子的长期稳定制剂和制备包含角质形成细胞生长因子的冻干组合物的方法。

公开(公告)号：WO2009015345A1

公开(公告)日：2009-01-29

申请号：PCT/US2008/071209

申请日：2008-07-25

Applicant: AMGEN INC. ,  TREUHEIT, Michael ,  RATNASWAMY, Gaya

Inventor： TREUHEIT, Michael ,  RATNASWAMY, Gaya

IPC: A61K9/06 ,  A61K9/00 ,  A61K38/00 ,  A61K39/00 ,  A61K47/48

CPC classification number: A61K9/0019 ,  A61K9/08 ,  A61K39/39591 ,  A61K47/6835 ,  C07K16/00 ,  C07K2319/30

Abstract: The invention herein described provides, among other things: methods for making protein formulations based on isoelectric points; protein formulations made by the methods; and uses of the methods and of the protein formulations.

Abstract translation: 本文所述的本发明尤其提供了：基于等电点制备蛋白质制剂的方法; 蛋白质制剂的制备方法; 以及方法和蛋白质制剂的使用。

公开(公告)号：WO1998014476A1

公开(公告)日：1998-04-09

申请号：PCT/US1997016196

申请日：1997-09-12

Applicant: AMGEN INC. ,  BREMS, David, N. ,  TREUHEIT, Michael, J.

Inventor： AMGEN INC.

IPC: C07K14/52

CPC classification number: C07K14/524 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26

Abstract: The subject invention relates to compositions of mpl ligands, comprising a full-length or truncated mpl ligand having a sequence of amino acids corresponding to amino acids 7-151 through 1-332, inclusive, of native human mpl ligand, optionally covalently linked to at least one water-soluble polymer; a buffering agent selected from glutamate, phosphate, histidine, imidazole, and acetate; an excipient selected from sorbitol, sucrose, mannitol, glycerol, polyethylene glycol, and non-polar amino acids; optionally, a detergent or lipid such as Tween; optionally, an antioxidant or chelating agent selected from glutathione, methionine, citrate and EDTA; and having a pH preferably ranging from 5.0 to 6.0 (inclusive). Such compositions may be liquid (preferably, aqueous), frozen (preferably, aqueous), or lyophilized.

Abstract translation: 本发明涉及mpl配体的组合物，其包含全长或截短的mpl配体，其具有对应于天然人mpl配体的氨基酸7-151至1-332的氨基酸序列，任选地共价连接到 至少一种水溶性聚合物; 选自谷氨酸盐，磷酸盐，组氨酸，咪唑和乙酸盐的缓冲剂; 选自山梨糖醇，蔗糖，甘露糖醇，甘油，聚乙二醇和非极性氨基酸的赋形剂; 任选地，洗涤剂或脂质如吐温; 任选地，选自谷胱甘肽，甲硫氨酸，柠檬酸盐和EDTA的抗氧化剂或螯合剂; 并且pH优选为5.0〜6.0（含）以上。 这样的组合物可以是液体（优选水性），冷冻（优选水性）或冻干。