公开(公告)号：WO2022201161A1

公开(公告)日：2022-09-29

申请号：PCT/IL2022/050327

申请日：2022-03-24

Applicant: CLAYMAN, Ralph V. ,  JIANG, Pengbo ,  SCHOENBERG, Mark ,  TSIPORI, Omer

Inventor： CLAYMAN, Ralph V. ,  JIANG, Pengbo ,  SCHOENBERG, Mark ,  TSIPORI, Omer

IPC: A61K31/722 ,  A61K9/00 ,  A61P13/04 ,  A61L24/00 ,  A61B17/22 ,  A61K47/10

Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.