公开(公告)号：WO2010115185A1

公开(公告)日：2010-10-07

申请号：PCT/US2010/029942

申请日：2010-04-05

Applicant: XCELLEREX, INC. ,  HUMACYTE, INC. ,  GUERTIN, Patrick, M. ,  GALLIHER, Parrish, M. ,  FISHER, Michael ,  CROWELL, Joseph, D. ,  TUOHEY, Colin, R. ,  NIKLASON, Laura, E. ,  TENTE, William, E. ,  DAHL, Shannon, M. ,  BLUM, Juliana ,  STRADER, Justin

Inventor： GUERTIN, Patrick, M. ,  GALLIHER, Parrish, M. ,  FISHER, Michael ,  CROWELL, Joseph, D. ,  TUOHEY, Colin, R. ,  NIKLASON, Laura, E. ,  TENTE, William, E. ,  DAHL, Shannon, M. ,  BLUM, Juliana ,  STRADER, Justin

IPC: C12N5/00

CPC classification number: C12M27/00 ,  C12M21/08 ,  C12M23/14 ,  C12M23/28 ,  C12M25/14 ,  C12M29/06

Abstract: A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.

Abstract translation: 单次使用，单次或多次组织，器官和移植物生物反应器和环境控制系统被设计为复制组织，器官或移植物生长所必需的条件，同时解决扩大组织生长的问题; 适应一次性或一次性格式; 作为提供细胞培养条件的全面环境控制的独立单元的操作。

公开(公告)号：WO2013040161A1

公开(公告)日：2013-03-21

申请号：PCT/US2012/055081

申请日：2012-09-13

Applicant: XCELLEREX, INC. ,  ERDENBERGER, Thomas ,  DAMREN, Richard L. ,  TUOHEY, Colin R. ,  FISHER, Michael ,  GALLIHER, Parrish M. ,  KENNEY, Jonathan A.

Inventor： ERDENBERGER, Thomas ,  DAMREN, Richard L. ,  TUOHEY, Colin R. ,  FISHER, Michael ,  GALLIHER, Parrish M. ,  KENNEY, Jonathan A.

IPC: B01F13/08

CPC classification number: B01F13/0818 ,  B01F3/04106 ,  B01F3/04531 ,  B01F7/0025 ,  B01F7/00633 ,  B01F7/162 ,  B01F13/0872 ,  B01F15/00714 ,  B01F15/0085 ,  B01F2003/04673 ,  B01F2015/0011 ,  B01F2215/0073 ,  C12M23/14 ,  C12M23/26 ,  C12M27/02

Abstract: Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are "receiver-less" retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.

Abstract translation: 公开了用于柔性容器反应容器的磁力搅拌混合系统。 在本发明的一个方面中，叶轮磁体和外部驱动磁体之间的磁耦合的取向被改变，使得联接器既不是严格的轴向也不是严格的径向。 还公开了“无接收器”保持器构造，由此一次性容器不需要具有限定杯或柱以接合可旋转搅拌器的刚性基座。