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    MRNA DELIVERY USING LIPID NANOPARTICLES
    1.
    发明申请
    MRNA DELIVERY USING LIPID NANOPARTICLES 审中-公开

    公开(公告)号：WO2022251953A1

    公开(公告)日：2022-12-08

    申请号：PCT/CA2022/050868

    申请日：2022-05-31

    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

    Inventor： KULKARNI, Jayesh ,  CHANDER, Nisha ,  BASHA, Genc ,  CIUFOLINI, Marco ,  WITZIGMANN, Dominik ,  CULLIS, Pieter

    IPC: A61K47/24 ,  A61K9/14 ,  A61K9/51 ,  A61P1/16 ,  A61P31/12 ,  A61P35/00 ,  C07F9/10 ,  C12N15/10 ,  C12N15/87

    Abstract: The present disclosure provides a lipid nanoparticle comprising encapsulated mRNA and at least 30 mol% of a sphingolipid (e.g. sphingomyelin (SM)), and at least one of a sterol and a hydrophilic polymer-lipid conjugate, the lipid nanoparticle comprising a core comprising an electron dense region and an aqueous portion surrounded at least partially by a lipid layer comprising a bilayer and the lipid nanoparticle exhibiting at least a 2-fold increase in gene expression in the liver, spleen and/or bone marrow at 4 or 24 hours post-injection as compared to a lipid nanoparticle encapsulating mRNA with an Onpattro™-type formulation of cationic, ionizable lipid/DSPC or ESM/cholesterol/PEG-lipid at 50/10/38.5/1.5, mol:mol, wherein the gene expression is measured in an animal model by detection of green fluorescent protein (GFP). Further provided are methods of medical treatment and uses of such lipid nanoparticles to treat or prevent a disease condition in a hepatic or non-hepatic tissue or organ.

    SULFUR-CONTAINING LIPIDS
    4.
    发明申请
    SULFUR-CONTAINING LIPIDS 审中-公开

    公开(公告)号：WO2022155728A1

    公开(公告)日：2022-07-28

    申请号：PCT/CA2022/050042

    申请日：2022-01-12

    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

    Inventor： CIUFOLINI, Marco ,  FERGUSON, Mai Lam

    IPC: C07C323/12 ,  A61K9/51 ,  A61K47/20 ,  C07C323/25 ,  C12N15/10 ,  C12N15/87

    Abstract: Provided herein is a compound having a structure of Formula (I): (Formula (I)) wherein: D is S, O or an ester; p is 1 to 6; L1 and/or L2 are independently linear or branched C1-C30 alkyl, optionally having one or more C=C double bonds of E or Z geometry; and wherein: if D is S then L1 and/or L2 are unsubstituted or substituted with one or more S; and if D is O or an ester, then L1 and/or L2 are substituted with one more S. The compound may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acid. Further provided are methods for making the compound.

    MULTI-SHELL HELMET WITH PIVOTABLE OUTER SHELL
    6.
    发明申请
    MULTI-SHELL HELMET WITH PIVOTABLE OUTER SHELL 审中-公开

    公开(公告)号：WO2022120498A1

    公开(公告)日：2022-06-16

    申请号：PCT/CA2021/051787

    申请日：2021-12-10

    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA [CA]/[CA]

    Inventor： CRIPTON, Peter Alec ,  CHUNG, Vivian Woan Jien ,  WHYTE, Thomas Christopher ,  BOOTH, Gabrielle Rose

    IPC: A42B3/064

    Abstract: Helmet prevent or mitigate cervical spine fractures, including the type of injuries associated with axial compression of the spine and fracture of the spine which may otherwise result in deformation and/or injury to the spinal cord. Helmets convert an impact force with a component aligned with the axis of the spine (a "spinally axial component") to rotational motion. In the event of a head-first impact, such helmets flexion of the neck so that the head and the cervical spine are not aligned (or less aligned) with the direction of an impact force, thereby mitigating the likelihood and/or severity of cervical spine fractures.

    CONTACTLESS CMUT OPERATION
    10.
    发明申请
    CONTACTLESS CMUT OPERATION 审中-公开

    公开(公告)号：WO2022067447A1

    公开(公告)日：2022-04-07

    申请号：PCT/CA2021/051378

    申请日：2021-10-01

    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

    Inventor： CRETU, Edmond ,  HERNANDEZ, Carlos Gerardo ,  ROHLING, Robert

    IPC: G10K15/06 ,  A61B8/00 ,  B60B1/02 ,  G01N29/24 ,  G01S7/534 ,  H01F19/02

    Abstract: Methods, systems, and techniques for the contactless operation of capacitive micromachined ultrasonic transducers (CMUTs) and CMUT arrays. Contactless operations refers to both the contactless transfer of energy and information between the transducer(s) and the controlling subsystem. A system includes a CMUT, a first alternating current voltage source, a first inductor electrically coupled to the first voltage source, and a second inductor electrically coupled to the CMUT. The second inductor is physically decoupled from, and positioned to be wirelessly coupled to, the first inductor. A contactless configuration is useful for a wide range of applications, from wearable transducers to high-end ultrasound imaging systems.

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