公开(公告)号：WO2012053011A3

公开(公告)日：2012-04-26

申请号：PCT/IN2011/000720

申请日：2011-10-18

Applicant: USV LIMITED ,  OMRAY, Ashok ,  CHOUDHARY, Varsha Shashank ,  BHIDE, Yogesh Sharad ,  PARSAI, Dinesh Yashawant

Inventor： OMRAY, Ashok ,  CHOUDHARY, Varsha Shashank ,  BHIDE, Yogesh Sharad ,  PARSAI, Dinesh Yashawant

IPC: A61K9/08 ,  A61K31/542 ,  A61K9/00

Abstract: Disclosed herein is a novel process for preparation of ophthalmic suspensions of Carbonic anhydrase inhibitor such as Brinzolamide. Said process is characterized in that it does not involve autoclaving of the active ingredient Brinzolamide. The invention further discloses ophthalmic suspensions comprising Brinzolamide and combination of Brinzolamide and beta-blocker prepared by the novel process.

公开(公告)号：WO2012042542A1

公开(公告)日：2012-04-05

申请号：PCT/IN2011/000683

申请日：2011-09-30

Applicant: USV LIMITED ,  SATHE, Dhananjay, Govind ,  MONDKAR, Harish, Kashinath ,  PATIL, Samadhan, Daulat ,  JADHAV, Tanaji, Shamrao ,  PATIL, Atul, Suresh

Inventor： SATHE, Dhananjay, Govind ,  MONDKAR, Harish, Kashinath ,  PATIL, Samadhan, Daulat ,  JADHAV, Tanaji, Shamrao ,  PATIL, Atul, Suresh

IPC: C08F8/00

CPC classification number: C08F8/00 ,  C08F126/02

Abstract: The present invention relates to desalination/desalting of polymer, in polyallylamine/crosslinked polymers by membrane separation techniques.

Abstract translation: 本发明涉及通过膜分离技术在聚烯丙胺/交联聚合物中脱盐/脱盐聚合物。

公开(公告)号：WO2009118753A2

公开(公告)日：2009-10-01

申请号：PCT/IN2009/000165

申请日：2009-03-09

Applicant: USV LIMITED ,  SATHE, Dhananjay, Govind ,  BHISE, Nandu, Baban ,  PATNEKAR, Subodh, Shashikant ,  DEORE, Raviraj, Bhatu

Inventor： SATHE, Dhananjay, Govind ,  BHISE, Nandu, Baban ,  PATNEKAR, Subodh, Shashikant ,  DEORE, Raviraj, Bhatu

IPC: C07D209/10 ,  A61K31/404 ,  A61P25/04 ,  A61P25/06 ,  A61P43/00 ,  A61P9/00

CPC classification number: C07D209/10

Abstract: The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof.

Abstract translation: 本发明涉及通过HPLC制备具有小于0.15％面积的式（I）的N-甲基-3-（1-甲基-4-哌啶基）-1H-吲哚-5-乙磺酰胺盐酸盐的改进方法， 3-（1-甲基-4-哌啶基）-1H-吲哚-5-乙磺酰胺（1A）及其中间体。

公开(公告)号：WO2009113092A2

公开(公告)日：2009-09-17

申请号：PCT/IN2009/000044

申请日：2009-01-13

Applicant: USV LIMITED ,  SATHE, Dhananjay, Govind ,  MONDKAR, Harish, Kashinath ,  JADHAV, Tanaji, Shamrao ,  HAGAVANE, Nitin, Nivrutti

Inventor： SATHE, Dhananjay, Govind ,  MONDKAR, Harish, Kashinath ,  JADHAV, Tanaji, Shamrao ,  HAGAVANE, Nitin, Nivrutti

IPC: C07C279/26

CPC classification number: C07C279/26

Abstract: Disclosed herein is the process for the preparation of 1-(4-chlorophenyl)-5- isopropyl-biguanide hydrochloride (Proguanil hydrochloride), Formula (I), an antimalarial agent.

Abstract translation: 本文公开了制备1-（4-氯苯基）-5-异丙基 - 双胍盐酸盐（盐酸胍胍），式（I），抗疟药剂的方法。

公开(公告)号：WO2009113091A3

公开(公告)日：2009-09-17

申请号：PCT/IN2009/000040

申请日：2009-01-13

Applicant: USV LIMITED ,  OMRAY, Ashok ,  SHENOY, Sandhya, Rajendra ,  SRIVASTAV, Monika

Inventor： OMRAY, Ashok ,  SHENOY, Sandhya, Rajendra ,  SRIVASTAV, Monika

IPC: A61K9/20 ,  A61K31/41 ,  A61K31/549

Abstract: Disclosed herein are pharmaceutical compositions comprising Valsartan and pharmaceutically acceptable additives optionally in combination with Hydrochlorothiazide and process for their preparation.

公开(公告)号：WO2008062463A2

公开(公告)日：2008-05-29

申请号：PCT/IN2007/000479

申请日：2007-10-12

Applicant: USV LIMITED ,  SATHE, Dhananjay, Govind ,  TARUR, Radhakrishnan, Venkatasubramanian ,  BHISE, Nandu, Baban ,  SHINDE, Ajit, Bhaskar ,  PARDESHI, Santosh

Inventor： SATHE, Dhananjay, Govind ,  TARUR, Radhakrishnan, Venkatasubramanian ,  BHISE, Nandu, Baban ,  SHINDE, Ajit, Bhaskar ,  PARDESHI, Santosh

IPC: C07D513/04 ,  A61K31/542 ,  A61P27/06

CPC classification number: C07D513/04

Abstract: Disclosed herein is an improved process for the preparation of (R)-(+)-4- (Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6- sulfonamide- 1,1 -dioxide (Brinzolamide) and novel intermediates thereof.

Abstract translation: 本文公开了制备（R） - （+） - 4-（乙基氨基）-3,4-二氢-2-（3-甲氧基丙基）-2H-噻吩并[3,2-e] -1 ，2-噻嗪-6-磺酰胺-1,1-二氧化物（布林酰胺）及其新型中间体。

公开(公告)号：WO2007072507A2

公开(公告)日：2007-06-28

申请号：PCT/IN2006/000500

申请日：2006-12-22

Applicant: USV LIMITED ,  TARUR, Venkatasubramanian, Radhakrishnan ,  SATHE, Dhananjay, Govind ,  BHISE, Nandu, Baban ,  SAWANT, Kamlesh, Digambar ,  NAIK, Tushar, Anil ,  SRIVASTAV, Neeraj ,  DEORE, Raviraj, Bhatu

Inventor： TARUR, Venkatasubramanian, Radhakrishnan ,  SATHE, Dhananjay, Govind ,  BHISE, Nandu, Baban ,  SAWANT, Kamlesh, Digambar ,  NAIK, Tushar, Anil ,  SRIVASTAV, Neeraj ,  DEORE, Raviraj, Bhatu

CPC classification number: C07D471/18

Abstract: Abstract The present disclosure relates to a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3 (4H)-one or Dolasetron base. It also discloses a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3 (4H)-one mesylate or Dolasetron mesylate. Further, the present disclosure relates to a process for producing Form I of Dolasetron base, and to the novel crystalline polymorphs, Form II, III, IV and V of Dolasetron base and industrial processes for producing them.

Abstract translation: 摘要本公开内容涉及内六氢-8-（3-吲哚基羰基氧基）-2,6-亚甲基-2H-喹嗪啉-3（4H） - 酮或多沙司琼碱的制备方法。 它还公开了制备内六氢-8-（3-吲哚基羰基氧基）-2,6-亚甲基-2H-喹嗪啉-3（4H） - 酮甲磺酸酯或甲磺酸多沙司琼的方法。 此外，本公开内容涉及制备杜拉司琼碱的形式I的方法，以及Dolasetron碱的新型结晶多晶型II，III，IV和V以及用于制备它们的工业方法。

公开(公告)号：WO2006103690A1

公开(公告)日：2006-10-05

申请号：PCT/IN2005/000164

申请日：2005-05-18

Applicant: USV LIMITED

Inventor： TARUR, Venkatasubramanian, Radhakrishnan ,  KADAM, Suresh, Mahadev ,  NAIK, Sanjay, Janardhan ,  GAVHANE, Sachin, Baban

IPC: C07D207/38 ,  A61K31/4015 ,  A61P3/10

CPC classification number: C07D207/38

Abstract: The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HC1 and 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide(I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride Form I (I), having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.

Abstract translation: 本发明公开了一种用于纯化反式-4-甲基环己胺HC1和4- [2-（3-乙基-4-甲基-2-羰基吡咯烷酰氨基）乙基]苯磺酰胺的新方法，其用于合成3-乙基 -2,5-二氢-4-甲基-N- [2- [4 - [[[[（反式-4-甲基环己基）氨基]羰基]氨基]磺酰基]苯基]乙基] -2-氧代-1H- 吡咯-1-甲酰胺（I），俗称格列美脲。 本发明还公开了具有不良的顺式异构体低于0.15％的格列美脲形式I（I）的新型纯化。 格列美脲（I）可用于治疗糖尿病。

公开(公告)号：WO2006051554A1

公开(公告)日：2006-05-18

申请号：PCT/IN2004/000346

申请日：2004-11-09

Applicant: USV LIMITED ,  BORBHUIYA, Ahmed, Monsur ,  RAO, Yada, Madhava ,  RAO, Laxmi, Srinivas ,  MAITI, Dipanwita ,  NIPHADKAR, Prabhakar, Milind ,  MISHRA, Shrikant

Inventor： BORBHUIYA, Ahmed, Monsur ,  RAO, Yada, Madhava ,  RAO, Laxmi, Srinivas ,  MAITI, Dipanwita ,  NIPHADKAR, Prabhakar, Milind ,  MISHRA, Shrikant

IPC: C07K14/61

CPC classification number: C07K14/61 ,  C07K1/20

Abstract: The present invention relates to a commercial process for purification of human Growth hormone obtained by DNA recombinant technique using hydrophobic interactive chromatography, efficient to separate clipped molecules of human growth hormone present as an impurity arising due to clipping positions present on the megamolecule of human growth hormone from the target human growth hormone molecule using a phenyl column, mixture of aqueous buffers and organic solvents as an eluant, followed by desalting, lypholization and the invention also relates to the process wherein the elution of clipped molecules of human growth hormone precedes the elution of target human growth hormone to obtain hGH of purity > 99.5%.

Abstract translation: 本发明涉及一种用于纯化人生长激素的商业方法，其通过使用疏水相互作用层析的DNA重组技术获得，其有效地分离存在于由人类生长激素的分子上存在的剪切位置而产生的作为杂质的人生长激素的限制分子 使用苯基柱的目标人生长激素分子，水性缓冲液和有机溶剂的混合物作为洗脱剂，然后脱盐，裂解和本发明还涉及其中人生长激素的剪切分子的洗脱先于 靶向人生长激素，以获得纯度> 99.5％的hGH。

公开(公告)号：WO2014167577A3

公开(公告)日：2014-10-16

申请号：PCT/IN2014/000188

申请日：2014-03-25

Applicant: USV LIMITED

Inventor： PATKAR, Laxmikant Narhari ,  MONDKAR, Harish Kashinath ,  AROTE, Nitin Dnyaneshwar ,  PATIL, Sachin Shivaji ,  JADHAV, Tanaji Shamrao ,  HAGAVANE, Nitin Nivrutti ,  BOPALKAR, Rajesh Ganpat

IPC: C07D401/12 ,  A61K31/4439

Abstract: The present invention relates to a process for preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof. The present invention relates to novel compounds, in particular Ethyl-3-{[(2-formyl-l-methyl-lH-benzimidazole-5-yl) carbonyl] -(2-pyridinyl) amino} propanoate and Ethyl-3-{[(2-dichloromethyl-l-methyl -lH-benzimidazole-5-yl)carbonyl]- (2-pyridinyl) amino}propanoate and process for preparation thereof. The present invention further relates to the use of these novel compounds in the preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof.