公开(公告)号：WO2012169892A3

公开(公告)日：2012-12-13

申请号：PCT/NL2012/050400

申请日：2012-06-08

Applicant: AM-PHARMA B.V. ,  AREND, Jacques Salomon Robert ,  VAN DEN BERG, Erik Jan ,  RAABEN, Willem

Inventor： AREND, Jacques Salomon Robert ,  VAN DEN BERG, Erik Jan ,  RAABEN, Willem

IPC: A61K38/46 ,  A61P13/12

Abstract: The invention relates to the field of medicine and in particular to means and methods for preserving renal function after a treatment with a risk of reducing renal function. The present invention also relates to means and methods for shortening the duration of renal replacement therapy, increasing the creatinine clearance and decreasing the adverse effects of medicaments.

公开(公告)号：WO2012169892A2

公开(公告)日：2012-12-13

申请号：PCT/NL2012050400

申请日：2012-06-08

Applicant: AM PHARMA BV ,  AREND JACQUES SALOMON ROBERT ,  VAN DEN BERG ERIK JAN ,  RAABEN WILLEM

Inventor： AREND JACQUES SALOMON ROBERT ,  VAN DEN BERG ERIK JAN ,  RAABEN WILLEM

IPC: A61K38/46

CPC classification number: A61K38/465 ,  C12Y301/03001 ,  G01N33/49 ,  G01N2800/52

Abstract: The invention relates to the field of medicine and in particular to means and methods for preserving renal function after a treatment with a risk of reducing renal function. The present invention also relates to means and methods for shortening the duration of renal replacement therapy, increasing the creatinine clearance and decreasing the adverse effects of medicaments.

Abstract translation: 本发明涉及药物领域，特别涉及在具有降低肾功能的风险的治疗后保留肾功能的方法和方法。 本发明还涉及缩短肾替代治疗持续时间的手段和方法，增加肌酐清除率和减少药物的不利影响。

公开(公告)号：WO2012134293A1

公开(公告)日：2012-10-04

申请号：PCT/NL2012/050212

申请日：2012-03-30

Applicant: HEATMATRIX GROUP B.V. ,  POSTMA, Ronald ,  SAKKO, Robert ,  DIKHOFF, Hans Constant ,  VAN DEN BERG, Erik Jan ,  VAN DEN BERG, Bart Jan

Inventor： POSTMA, Ronald ,  SAKKO, Robert ,  DIKHOFF, Hans Constant ,  VAN DEN BERG, Erik Jan ,  VAN DEN BERG, Bart Jan

IPC: B01F5/04 ,  B01F3/02 ,  F02M25/07

CPC classification number: B01F5/0456 ,  B01F5/0493 ,  F02M26/32

Abstract: A mixing device (10) for mixing a first fluid and a second fluid comprises a housing (12) which is provided with a first inlet (20) for the first fluid, a second inlet (27) for the second fluid, a mixing chamber (42) for mixing the first fluid and the second fluid into a mixture of the first fluid and the second fluid, and an outlet (26) for the mixture of the first fluid and the second fluid. The housing (12) is provided with a plurality of heat exchanger tubes (36) having tube walls (37) which are situated next to each other and extend substantially parallel to each other. The interiors of the tube walls (37) define elongate first channels (38). Each elongate first channel (38) comprises a first supply opening (65) and a first discharge opening (66,81). The first supply openings (65) are in fluid communication with the first inlet (20) for the first fluid. At least a number of the first discharge openings (66,81) are in fluid communication with the mixing chamber (42). The tube walls (37) of adjacent heat exchanger tubes (36) are connected to each other so as to define elongate second channels (58) on the exterior of the tube walls (37). Each elongate second channel (58) comprises a second supply opening (75) and a second discharge opening (76). The elongate second channels (58) are in fluid communication with the second inlet (27) for the second fluid and with the mixing chamber (42) by means of the second openings (75,76).

Abstract translation: 用于混合第一流体和第二流体的混合装置（10）包括壳体（12），其设置有用于第一流体的第一入口（20），用于第二流体的第二入口（27），混合室 （42），用于将第一流体和第二流体混合成第一流体和第二流体的混合物，以及用于混合第一流体和第二流体的出口（26）。 壳体（12）设置有多个彼此相邻并且基本上彼此平行地延伸的具有管壁（37）的热交换器管（36）。 管壁（37）的内部限定细长的第一通道（38）。 每个细长的第一通道（38）包括第一供应开口（65）和第一排出口（66,81）。 第一供应开口（65）与用于第一流体的第一入口（20）流体连通。 至少多个第一排出口（66,81）与混合室（42）流体连通。 相邻的热交换器管（36）的管壁（37）彼此连接，以在管壁（37）的外部限定细长的第二通道（58）。 每个细长的第二通道（58）包括第二供应开口（75）和第二排放口（76）。 细长的第二通道（58）与用于第二流体的第二入口（27）和借助于第二开口（75,76）与混合室（42）流体连通。