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    APPARATUSES FOR AND METHODS OF PROCESSING CELLS AND RELATED STRUCTURES
    1.
    发明申请
    APPARATUSES FOR AND METHODS OF PROCESSING CELLS AND RELATED STRUCTURES 审中-公开
    装置和处理细胞的方法及相关结构

    公开(公告)号：WO2012120102A1

    公开(公告)日：2012-09-13

    申请号：PCT/EP2012/054056

    申请日：2012-03-08

    Applicant: UNIVERSITEIT LEIDEN ,  KOPLA B.V. ,  VULTO, Paul ,  TRIETSCH, Sebastiaan Johannes ,  VAN DER LINDEN, Heiko Jan ,  JOORE, Adrianus Theodorus ,  HANKEMEIER, Thomas

    Inventor： VULTO, Paul ,  TRIETSCH, Sebastiaan Johannes ,  VAN DER LINDEN, Heiko Jan ,  JOORE, Adrianus Theodorus ,  HANKEMEIER, Thomas

    IPC: C12M3/00

    CPC classification number: C12M27/18 ,  B01F13/0083 ,  B01L3/502746 ,  B01L3/56 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086 ,  B01L2400/088 ,  C12M23/16 ,  C12M23/34 ,  C12M29/10 ,  C12M35/08 ,  Y10T137/0318

    Abstract: Apparatus for processing life-based organic particles, including particles selected from the list comprising cells, cellular spheroids, tissues, eukaryotes, micro-organisms, organs or embryos, comprises a hollow volume (10) that (a) is internally divided into at least first (14), second (16) and third (17) sub-volumes by at least two phaseguides (12, 13) formed inside the volume and (b) includes parts that are relatively upstream and relatively downstream when judged with reference to the movement of a meniscus or a bulk liquid in the volume (10). The apparatus includes at least first, second and third fluid conduits (19, 21, 22) connected to permit fluid communication between the upstream exterior of the volume (10) and a respective said sub-volume (14, 16, 17); and at least one further conduit (24) connected to permit fluid communication between the downstream exterior of the volume (10) and a said sub-volume. The first sub-volume (14) contains one or more life-based particles supported in or by a gel or gel-like substance; and the second sub-volume (16) communicates with the first sub-volume so as to permit transport of substances between the first and second sub-volumes (14, 16) and contains at least one gel or gel-like substance.

    Abstract translation: 用于处理基于生命的有机颗粒的装置，包括选自包括细胞，细胞球体，组织，真核生物，微生物，器官或胚胎的颗粒的颗粒，包括中空体积（10），其中（a）至少内部分为 第一（14），第二（16）和第三（17）子体积，形成在容积内形成的至少两个相位导体（12,13），（b）包括相对上游和相对下游的部分， 弯液面或大量液体在体积（10）中的移动。 该装置包括至少第一，第二和第三流体导管（19,21,22），其被连接以允许容积（10）的上游外部与相应的所述子体积（14,16,17）之间的流体连通。 以及至少一个另外的导管（24），其连接以允许容积（10）的下游外部与所述子体积之间的流体连通。 第一子体积（14）包含一种或多种在凝胶或凝胶状物质中或由凝胶或类似物质负载的基于生命的颗粒; 并且所述第二子体积（16）与所述第一子体积连通以允许物质在所述第一和第二子体积（14,16）之间运输并且包含至少一种凝胶或凝胶状物质。

    APPARATUS FOR AND METHODS OF PROCESSING LIQUIDS OR LIQUID-BASED SUBSTANCES
    2.
    发明申请
    APPARATUS FOR AND METHODS OF PROCESSING LIQUIDS OR LIQUID-BASED SUBSTANCES 审中-公开

    公开(公告)号：WO2012120101A4

    公开(公告)日：2012-09-13

    申请号：PCT/EP2012/054053

    申请日：2012-03-08

    Applicant: UNIVERSITEIT LEIDEN ,  VULTO, Paul ,  TRIETSCH, Sebastiaan Johannes ,  VAN DER LINDEN, Heiko Jan ,  HANKEMEIER, Thomas

    Inventor： VULTO, Paul ,  TRIETSCH, Sebastiaan Johannes ,  VAN DER LINDEN, Heiko Jan ,  HANKEMEIER, Thomas

    IPC: B01L3/00 ,  B01F13/00 ,  F16K99/00

    Abstract: Apparatus for processing liquids or liquid-based substances includes a plurality of volumes at least two of which are defined at least in part by one or more phaseguides inside the volume and/or in a conduit connected thereto for controlling aliquoting of one or more liquids or liquid-based substances inside the volume. Each volume has an upstream and downstream side with respect to meniscus advancement direction via which it may be filled with or emptied of one or more liquids or liquid-based substances. The apparatus also includes at least one common upstream-side conduit connected to supply a liquid or liquid-based substance via a plurality of the inlet or extraction conduits, a plurality of the phaseguides exhibiting a predetermined level of stability and one or more of the phaseguides exhibiting a predetermined different stability compared with the stability of at least one of the other phaseguides whereby to control the preference order in which the volumes fill and/or empty. The stability is determined by the value and radius of an acute angle along a said phaseguide at the downstream side of the phaseguide.

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