公开(公告)号：WO2022174346A1

公开(公告)日：2022-08-25

申请号：PCT/CA2022/050232

申请日：2022-02-17

Applicant: TAN, Bo ,  VENKATAKRISHNAN, Krishnan ,  GANESH, Swarna ,  RAVINDRA, Haldavnekar Rupa

Inventor： TAN, Bo ,  VENKATAKRISHNAN, Krishnan ,  GANESH, Swarna ,  RAVINDRA, Haldavnekar Rupa

IPC: G01N21/65 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/483 ,  G16H50/20

Abstract: Embodiments of a computing device and methods of providing a cancer assessment for a patient are described. The method involves isolating a volume of a fluid from a fluid sample of the patient, the volume of fluid including at least one biomarker; adding at least a portion of the volume of fluid to a nanosensor comprising nanoparticles configured to capture the at least one biomarker and amplify signals emitted by the at least one biomarker during Raman spectroscopy; performing Raman spectroscopy on the volume of fluid on the nanosensor to produce a sample Raman spectrum having amplified signals indicating the presence of the at least one biomarker on the nanosensor; processing the sample Raman spectrum using data from template Raman spectra from known cancer samples; and based on the detected one or more cancer characteristics, providing the cancer assessment of the patient.

公开(公告)号：WO2022020959A8

公开(公告)日：2022-02-03

申请号：PCT/CA2021/051064

申请日：2021-07-29

Applicant: VENKATAKRISHNAN, Krishnan ,  TAN, Bo

Inventor： VENKATAKRISHNAN, Krishnan ,  TAN, Bo

IPC: C30B29/02 ,  B01J2/00 ,  B82Y40/00 ,  C30B30/00 ,  C30B35/00 ,  G01N21/65 ,  G01N33/52 ,  H05H6/00

Abstract: Methods of synthesizing nanoparticles of an isotope using a laser beam are described herein. The methods include generating the laser beam, directing the laser beam to the target to convert the target into a plasma state, and bombarding the target in the plasma state with the laser beam to maintain the target in the plasma state and synthesize the nanoparticles of the isotope. During bombarding the target in the plasma state with the laser beam, the laser beam is configured to have a pulse frequency and peak laser intensity that accelerates electrons in the plasma state and maintains the plasma state at a temperature high enough to provide for the synthesis of the nanoparticles of the isotope. Apparatuses for synthesizing nanoparticles of an isotope using a laser beam are also described herein.

公开(公告)号：WO2022020959A1

公开(公告)日：2022-02-03

申请号：PCT/CA2021/051064

申请日：2021-07-29

Applicant: VENKATAKRISHNAN, Krishnan ,  TAN, Bo

Inventor： VENKATAKRISHNAN, Krishnan ,  TAN, Bo

IPC: C30B29/02 ,  B01J2/00 ,  B82Y40/00 ,  C30B30/00 ,  C30B35/00 ,  G01N21/65 ,  G01N33/52 ,  H05H6/00

Abstract: Methods of synthesizing nanoparticles of an isotope using a laser beam are described herein. The methods include generating the laser beam, directing the laser beam to the target to convert the target into a plasma state, and bombarding the target in the plasma state with the laser beam to maintain the target in the plasma state and synthesize the nanoparticles of the isotope. During bombarding the target in the plasma state with the laser beam, the laser beam is configured to have a pulse frequency and peak laser intensity that accelerates electrons in the plasma state and maintains the plasma state at a temperature high enough to provide for the synthesis of the nanoparticles of the isotope. Apparatuses for synthesizing nanoparticles of an isotope using a laser beam are also described herein.