公开(公告)号：WO2006059247A8

公开(公告)日：2007-04-26

申请号：PCT/IB2005004126

申请日：2005-10-25

Applicant: UNIV WESTERN ONTARIO ,  HEINRICHS DAVID E ,  VERMEIREN CHRISTIE

Inventor： HEINRICHS DAVID E ,  VERMEIREN CHRISTIE

IPC: A61K39/40 ,  A61K31/7088 ,  A61K39/085 ,  A61K39/395 ,  A61P31/04 ,  C12Q1/14 ,  C12Q1/18 ,  C12Q1/68

CPC classification number: C07K14/31 ,  A61K38/00 ,  A61K39/00

Abstract: Iron-regulated surface determinant proteins IsdA, IsdB and IsdC from Staphylococcus aureus, as well as antibodies, antisense nucleic acids and siRNA specific to IsdA, IsdB or IsdC are used as vaccines and in method for treating or preventing a disease or condition associated with S. aureus infections Screening assays for identifying agents that inhibit or interfere with the expression level and/or function of IsdA, IsdB or IsdC are also described.

Abstract translation: 来自金黄色葡萄球菌的铁调节表面决定簇蛋白IsdA，IsdB和IsdC以及IsdA，IsdB或IsdC特异性的抗体，反义核酸和siRNA用作疫苗和用于治疗或预防与S相关的疾病或病症的方法 金黄色葡萄球菌感染还描述了用于鉴定抑制或干扰IsdA，IsdB或IsdC的表达水平和/或功能的药剂的筛选试验。

公开(公告)号：WO2008152447A2

公开(公告)日：2008-12-18

申请号：PCT/IB2007/004635

申请日：2007-10-30

Applicant: THE UNIVERSITY OF WESTERN ONTARIO ,  HEINRICHS, David, E. ,  GRIGG, Jason, C. ,  VERMEIREN, Christie ,  MURPHY, Michael, E., P.

Inventor： HEINRICHS, David, E. ,  GRIGG, Jason, C. ,  VERMEIREN, Christie ,  MURPHY, Michael, E., P.

IPC: C07K14/31 ,  A61K39/085 ,  A61K39/40 ,  A61P31/04 ,  C07K16/12 ,  C12N15/31

CPC classification number: C07K14/31 ,  A61K39/085 ,  A61K2039/505 ,  C07K16/1271 ,  C12Q1/18 ,  G01N33/56938

Abstract: The present invention provides novel anti-infectives that act on Staphylococcus aureus (S. aureus) iron-regulated surface determinants, IsdA, IsdB, IsdC, IsdH (or HarA).

Abstract translation: 本发明提供了新的抗金黄色葡萄球菌（S.

公开(公告)号：WO2008152447A3

公开(公告)日：2011-03-03

申请号：PCT/IB2007004635

申请日：2007-10-30

Applicant: UNIV WESTERN ONTARIO ,  HEINRICHS DAVID E ,  GRIGG JASON C ,  VERMEIREN CHRISTIE ,  MURPHY MICHAEL E P

Inventor： HEINRICHS DAVID E ,  GRIGG JASON C ,  VERMEIREN CHRISTIE ,  MURPHY MICHAEL E P

IPC: C07K14/31 ,  A61K39/085 ,  A61K39/40 ,  A61P31/04 ,  C07K16/12 ,  C12N15/31

CPC classification number: C07K14/31 ,  A61K39/085 ,  A61K2039/505 ,  C07K16/1271 ,  C12Q1/18 ,  G01N33/56938

Abstract: Vaccines comprising the NEAT domain of iron-regulated surface determinant (Isd) proteins IsdA, IsdB, IsdC, and IsdH (HarA) from Staphylococcus aureus, as well as antibodies, antisense nucleic acids and siRNA specific to the NEAT domains of IsdA, IsdB. IsdC or IsdH (HarA) are described Screening assays for identifying agents that inhibit or interfere with the expression level and/or function of IsdA, IsdB, IsdC or IsdH (HarA) NEAT domain arc also described.

Abstract translation: 包含来自金黄色葡萄球菌的铁调节表面决定簇（Isd）蛋白IsdA，IsdB，IsdC和IsdH（HarA）的NEAT结构域的疫苗，以及IsdA，IsdB的NEAT结构域特异性的抗体，反义核酸和siRNA。 IsdC或IsdH（HarA）描述了用于鉴定抑制或干扰IsdA，IsdB，IsdC或IsdH（HarA）NEAT结构域的表达水平和/或功能的试剂的筛选试验。

公开(公告)号：WO2006059247A3

公开(公告)日：2006-10-05

申请号：PCT/IB2005004126

申请日：2005-10-25

Applicant: UNIV WESTERN ONTARIO ,  HEINRICHS DAVID E ,  VERMEIREN CHRISTIE

Inventor： HEINRICHS DAVID E ,  VERMEIREN CHRISTIE

IPC: A61K39/40 ,  A61K31/7088 ,  A61K39/085 ,  A61K39/395 ,  A61P31/04 ,  C12Q1/14 ,  C12Q1/18 ,  C12Q1/68

CPC classification number: C07K14/31 ,  A61K38/00 ,  A61K39/00

Abstract: Iron-regulated surface determinant proteins IsdA, IsdB and IsdC from Staphylococcus aureus, as well as antibodies, antisense nucleic acids and siRNA specific to IsdA, IsdB or IsdC are used as vaccines and in method for treating or preventing a disease or condition associated with S. aureus infections Screening assays for identifying agents that inhibit or interfere with the expression level and/or function of IsdA, IsdB or IsdC are also described.

Abstract translation: 来自金黄色葡萄球菌的铁调节表面决定簇蛋白IsdA，IsdB和IsdC以及IsdA，IsdB或IsdC特异性的抗体，反义核酸和siRNA用作疫苗和用于治疗或预防与S相关的疾病或病症的方法 金黄色葡萄球菌感染还描述了用于鉴定抑制或干扰IsdA，IsdB或IsdC的表达水平和/或功能的药剂的筛选试验。

公开(公告)号：WO2006059247A2

公开(公告)日：2006-06-08

申请号：PCT/IB2005/004126

申请日：2005-10-25

Applicant: THE UNIVERSITY OF WESTERN ONTARIO ,  HEINRICHS, David, E. ,  VERMEIREN, Christie

Inventor： HEINRICHS, David, E. ,  VERMEIREN, Christie

CPC classification number: C07K14/31 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention provides novel anti-infectives that act on Staphylococcus aureus (S. aureus) iron-regulated surface determinants, IsdA, IsdB, and IsdC.

Abstract translation: 本发明提供了作用于金黄色葡萄球菌（金黄色葡萄球菌）铁调节表面决定簇IsdA，IsdB和IsdC的新型抗感染剂。