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1.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE ALDH GENE 审中-公开使用肠杆菌属家族细菌与ALDH基因的衰减表达生产L-氨基酸的方法
公开(公告)号：WO2007086546A8
公开(公告)日：2011-05-05
申请号：PCT/JP2007051339
申请日：2007-01-23
Applicant: AJINOMOTO KK , FILIPPOV DMITRIY VLADIMIROVICH , VOROSHILOVA ELVIRA BORISOVNA , LEONOVA TATYANA VIKTOROVNA , GUSYATINER MIKHAIL MARKOVICH
Inventor： FILIPPOV DMITRIY VLADIMIROVICH , VOROSHILOVA ELVIRA BORISOVNA , LEONOVA TATYANA VIKTOROVNA , GUSYATINER MIKHAIL MARKOVICH
CPC classification number: C12N9/0008 , C12P13/04 , C12Y102/01004
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the aldH gene.
Abstract translation: 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，该方法已被修饰以减弱aldH基因的表达。
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2.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WHICH HAS BEEN MODIFIED TO ABOLISH CURLI FORMATION 审中-公开一种使用已经被修饰以抵抗CURLI形成的肠杆菌家族的细菌产生L-氨基酸的方法
公开(公告)号：WO2007119880A9
公开(公告)日：2008-01-31
申请号：PCT/JP2007058570
申请日：2007-04-13
Applicant: AJINOMOTO KK , RYBAK KONSTANTIN VYACHESLAVOVI , SKOROKHODOVA ALEKSANDRA YURIEV , VOROSHILOVA ELVIRA BORISOVNA , GUSYATINER MIKHAIL MARKOVICH
Inventor： RYBAK KONSTANTIN VYACHESLAVOVI , SKOROKHODOVA ALEKSANDRA YURIEV , VOROSHILOVA ELVIRA BORISOVNA , GUSYATINER MIKHAIL MARKOVICH
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to abolish curli formation, particularly, by attenuation of expression of the csgBAC and/or csgDEFG operons.
Abstract translation: 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已被修饰以消除curli形成，特别是通过减少csgBAC的表达 和/或csgDEFG操纵子。
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3.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THEENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA 审中-公开一种使用细胞因子细菌产生L-氨基酸的方法，其具有用于小RNA的基因编码的衰减表达
公开(公告)号：WO2007119574A2
公开(公告)日：2007-10-25
申请号：PCT/JP2007/056752
申请日：2007-03-22
Applicant: AJINOMOTO CO., INC. , RYBAK, Konstantin, Vyacheslavovich , SKOROKHODOVA, Aleksandra, Yurievna , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich , LEONOVA, Tatyana, Viktorovna , KOZLOV, Yury, Ivanovich , UEDA, Takuji
Inventor： RYBAK, Konstantin, Vyacheslavovich , SKOROKHODOVA, Aleksandra, Yurievna , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich , LEONOVA, Tatyana, Viktorovna , KOZLOV, Yury, Ivanovich , UEDA, Takuji
IPC: C12N1/00
CPC classification number: C12P13/04
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea , which has been modified to attenuate expression of a gene coding for sRNA.
Abstract translation: 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已被修饰以减弱编码sRNA的基因的表达。
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4.发明申请METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED LEUO EXPRESSION 审中-公开使用灭菌细菌表达的肠杆菌家族细菌生产L-氨基酸的方法
公开(公告)号：WO2006103936A3
公开(公告)日：2007-06-21
申请号：PCT/JP2006305194
申请日：2006-03-09
Applicant: AJINOMOTO KK , RYBAK KONSTANTIN VYACHESLAVOVI , VOROSHILOVA ELVIRA BORISOVNA , LEONOVA TATYANA VIKTOROVNA , KOZLOV YURY IVANOVICH
Inventor： RYBAK KONSTANTIN VYACHESLAVOVI , VOROSHILOVA ELVIRA BORISOVNA , LEONOVA TATYANA VIKTOROVNA , KOZLOV YURY IVANOVICH
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the leuO gene.
Abstract translation: 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的L-氨基酸的生产方法，其已被修饰以减弱leuO基因的表达。
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5.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY HAVING EXPRESSION OF THE NAC GENE ATTENUATED 审中-公开使用具有表达NAC基因的肠杆菌属家族的细菌产生L-氨基酸的方法衰减
公开(公告)号：WO2006103935A2
公开(公告)日：2006-10-05
申请号：PCT/JP2006/305190
申请日：2006-03-09
Applicant: AJINOMOTO CO., INC. , FILIPPOV, Dmitriy, Vladimirovich , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich
Inventor： FILIPPOV, Dmitriy, Vladimirovich , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich
CPC classification number: C07K14/245 , C12P13/04
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea , which has been modified to attenuate expression of the nac gene.
Abstract translation: 本发明提供使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已被修饰以减弱nac基因的表达。
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Patent Agency Ranking6.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY 审中-公开使用肠杆菌属家禽生产L-氨基酸的方法
公开(公告)号：WO2006088235A1
公开(公告)日：2006-08-24
申请号：PCT/JP2006/303215
申请日：2006-02-16
Applicant: AJINOMOTO CO., INC. , FILIPPOV, Dmitriy, Vladimirovich , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich , RYBAK, Konstantin, Vyacheslavovich , SHEREMET'EVA, Marina, Evgenievna , SKOROKHODOVA, Aleksandra, Yurievna , KOZLOV, Yury, Ivanovich
Inventor： FILIPPOV, Dmitriy, Vladimirovich , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich , RYBAK, Konstantin, Vyacheslavovich , SHEREMET'EVA, Marina, Evgenievna , SKOROKHODOVA, Aleksandra, Yurievna , KOZLOV, Yury, Ivanovich
IPC: C12P13/04
CPC classification number: C12P13/04
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea,wherein said bacterium has attenuated expression of a gene encoding a toxin of bacterial toxin-antitoxin pairs.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其中所述细菌具有减毒的细菌毒素 - 抗毒素对毒素的基因的表达。
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7.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY HAVING EXPRESSION OF THE BOLA GENE ATTENUATED 审中-公开使用具有表达BOLA基因的肠杆菌属家族的细菌产生L-氨基酸的方法衰减
公开(公告)号：WO2006088232A1
公开(公告)日：2006-08-24
申请号：PCT/JP2006/303212
申请日：2006-02-16
Applicant: AJINOMOTO CO., INC. , FILIPPOV, Dmitriy, Vladimirovich , VOROSHILOVA, Elvira, Borisovna , LEONOVA, Tatyana, Viktorovna , KOZLOV, Yury, Ivanovich
Inventor： FILIPPOV, Dmitriy, Vladimirovich , VOROSHILOVA, Elvira, Borisovna , LEONOVA, Tatyana, Viktorovna , KOZLOV, Yury, Ivanovich
IPC: C12P13/04
CPC classification number: C12P13/04
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the bolA gene.
Abstract translation: 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已被修饰以减弱bolA基因的表达。
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8.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY, HAVING ATTENUATED EXPRESSION OF GENES ENCODING A LYSINE/ARGININE/ORNITHINE TRANSPORTER 审中-公开一种使用肠杆菌属家族的细菌产生L-氨基酸的方法，具有编码LYSINE / ARGININE / ORNITHINE TRANSPORTER的基因的衰减表达
公开(公告)号：WO2011152568A1
公开(公告)日：2011-12-08
申请号：PCT/JP2011/063304
申请日：2011-06-03
Applicant: AJINOMOTO CO.,INC. , ROSTOVA, Yulia Georgievna , VOROSHILOVA, Elvira Borisovna , GUSYATINER, Mikhail Markovich
IPC: C07K14/245 , C12N9/14 , C12P13/10 , C12P13/14
CPC classification number: C12P13/10 , C07K14/245 , C12N15/70 , C12P13/08
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea , in which expression of the gene encoding a lysine/arginine/ornithine transporter has been attenuated.
Abstract translation: 本发明提供使用细菌的肠杆菌科，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其中编码赖氨酸/精氨酸/鸟氨酸转运蛋白的基因的表达已被减弱。
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9.发明申请METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE chaC GENE 审中-公开使用肠杆菌属细菌的细菌生产含有氨基酸的方法，其具有慢性基因的衰减表达
公开(公告)号：WO2009022755A1
公开(公告)日：2009-02-19
申请号：PCT/JP2008/064772
申请日：2008-08-13
Applicant: AJINOMOTO CO., INC. , RYBAK, Konstantin, Vyacheslavovich , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich
Inventor： RYBAK, Konstantin, Vyacheslavovich , VOROSHILOVA, Elvira, Borisovna , GUSYATINER, Mikhail, Markovich
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea , which has been modified to attenuate expression of the chaC gene.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的L-氨基酸的制造方法，其已经被修饰以减弱chaC基因的表达。
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10.发明申请A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE YRAH-R CLUSTER 审中-公开使用具有衰减的YRAH-R聚类表达的肠杆菌属家族的细菌生产L-氨基酸的方法
公开(公告)号：WO2008004682A1
公开(公告)日：2008-01-10
申请号：PCT/JP2007/063617
申请日：2007-07-02
Applicant: AJINOMOTO CO., INC. , FILIPPOV, Dmitriy Vladimirovich , VOROSHILOVA, Elvira Borisovna , GUSYATINER, Mikhail Markovich
Inventor： FILIPPOV, Dmitriy Vladimirovich , VOROSHILOVA, Elvira Borisovna , GUSYATINER, Mikhail Markovich
CPC classification number: C12P13/04
Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea , which has been modified to attenuate expression of the yraH-R cluster.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已经被修饰以减弱yraH-R簇的表达。
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