公开(公告)号：WO2007052121A3

公开(公告)日：2007-05-10

申请号：PCT/IB2006/003049

申请日：2006-10-23

Applicant: WARNER-LAMBERT COMPANY LLC ,  NICHOLS, William, Michael ,  LEE, Willy ,  KULKARNI, Neema

Inventor： NICHOLS, William, Michael ,  LEE, Willy ,  KULKARNI, Neema

IPC: A61K9/50 ,  A61K31/485 ,  A61K9/70

Abstract: Various embodiments of the present invention relate to compositions and methods that have multi-layer coating technology that provide improved taste masking. This technology enables taste masked drug substances to withstand hydration due to saliva in the mouth and aqueous solutions.

公开(公告)号：WO2007029098A1

公开(公告)日：2007-03-15

申请号：PCT/IB2006/002447

申请日：2006-08-29

Applicant: WARNER-LAMBERT COMPANY LLC ,  MADIT, Nicolas

Inventor： MADIT, Nicolas

IPC: A61K9/48 ,  A61K31/205

CPC classification number: A61K31/205 ,  A61K9/4816 ,  A61K9/4858

Abstract: The present invention provides a delivery system comprising: (a) a container which is a formed body obtained from a film forming composition comprising at least one polysaccharide or polysaccharide derivative; (b) a liquid fill comprising a matrix composition of at least one solvent which is both polar and hygroscopic or a mixture of solvents each of which is both polar and hygroscopic; and (c) an active agent or a mixture of active agents wherein the active agent is soluble in said polar and hygroscopic solvent or mixture of polar and hygroscopic solvents, and a process for the preparation of said delivery system. Preferably the delivery system is a HPMC capsule filled with a matrix composition comprising glycerol and an active agent such as L-Carnitine .

Abstract translation: 本发明提供了一种递送系统，包括：（a）由包含至少一种多糖或多糖衍生物的成膜组合物获得的成形体的容器; （b）液体填充物，其包含至少一种极性和吸湿性的溶剂的基质组合物或各自为极性和吸湿性的溶剂混合物; 和（c）活性剂或活性剂的混合物，其中活性剂可溶于所述极性和吸湿溶剂或极性和吸湿溶剂的混合物中，以及制备所述递送系统的方法。 优选地，递送系统是填充有包含甘油和活性剂如L-肉碱的基质组合物的HPMC胶囊。

公开(公告)号：WO2006114705A1

公开(公告)日：2006-11-02

申请号：PCT/IB2006/001067

申请日：2006-04-18

Applicant: WARNER-LAMBERT COMPANY LLC ,  MACHIKENAS, Dainius ,  SEADEEK, Christopher, Scott

Inventor： MACHIKENAS, Dainius ,  SEADEEK, Christopher, Scott

IPC: G01N21/23

CPC classification number: G01N21/23

Abstract: Methods, devices, and systems for targeting and characterizing crystalline regions of solid-state samples using birefringence are disclosed. The information gained from a birefringence image serves to target crystalline regions with complementary techniques such as x-ray diffraction, infrared spectroscopy, Raman spectroscopy, and the like.

Abstract translation: 公开了用于使用双折射定向和表征固态样品的结晶区域的方法，装置和系统。 从双折射图像获得的信息用于使用诸如x射线衍射，红外光谱，拉曼光谱等的互补技术来对结晶区域进行目标。

公开(公告)号：WO2006103559A1

公开(公告)日：2006-10-05

申请号：PCT/IB2006/000900

申请日：2006-03-20

Applicant: WARNER-LAMBERT COMPANY LLC ,  FAVOR, David, Alan ,  JOHNSON, Douglas, Scott ,  REPINE, Joseph, Thomas ,  WHITE, Andrew, David

Inventor： FAVOR, David, Alan ,  JOHNSON, Douglas, Scott ,  REPINE, Joseph, Thomas ,  WHITE, Andrew, David

IPC: C07D471/04 ,  A61K31/55 ,  A61K31/551

CPC classification number: C07D471/04 ,  A61K31/55 ,  A61K31/5513

Abstract: Compounds of formula 1 are disclosed, wherein G, D, A, Q, Y, Z, and R 1 through R 10 are defined in the specification. Also provided are descriptions of processes for preparing compounds of formula 1, intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

Abstract translation: 公开了式1的化合物，其中在说明书中定义了G，D，A，Q，Y，Z和R 1至R 10。 还提供了制备式1化合物的方法，用于制备式1的中间体和含有这些化合物的药物组合物及其在治疗中枢神经系统疾病和其它病症中的用途的描述。

公开(公告)号：WO2006097828A2

公开(公告)日：2006-09-21

申请号：PCT/IB2006/000584

申请日：2006-03-13

Applicant: WARNER-LAMBERT COMPANY LLC ,  LEACH, Karen Lynn

Inventor： LEACH, Karen Lynn

CPC classification number: C12Q1/18 ,  G01N33/5014

Abstract: The invention provides a method of identifying the myelosuppressive liability of antibacterial oxazolidinone compounds.

Abstract translation: 本发明提供了鉴定抗菌恶唑烷酮化合物的骨髓抑制负担的方法。

公开(公告)号：WO2006095238A1

公开(公告)日：2006-09-14

申请号：PCT/IB2006/000485

申请日：2006-02-27

Applicant: WARNER-LAMBERT COMPANY LLC ,  REILY, Michael, David ,  ROBOSKY, Lora, Cowgill ,  WADE, Kimberly, Jane

Inventor： REILY, Michael, David ,  ROBOSKY, Lora, Cowgill ,  WADE, Kimberly, Jane

IPC: G01R33/46

CPC classification number: G01N24/08 ,  G01R33/465

Abstract: The invention provides a method for identifying a compound that modulates sebum production or that modulates the amount of at least one individual lipid component of a sebum sample utilizing nuclear magnetic resonance (NMR) spectroscopy.

Abstract translation: 本发明提供了一种用于鉴定调节皮脂产生的化合物或利用核磁共振（NMR）光谱法调节皮脂样品的至少一种单独的脂质成分的量的方法。

公开(公告)号：WO2006092689A1

公开(公告)日：2006-09-08

申请号：PCT/IB2006/000346

申请日：2006-02-20

Applicant: WARNER-LAMBERT COMPANY LLC ,  KINDT, Kristian, Erich ,  SZEKELY-KLEPSER, Gabriella ,  WADE, Kimberly, Jane ,  LI, Wenlin

Inventor： KINDT, Kristian, Erich ,  SZEKELY-KLEPSER, Gabriella ,  WADE, Kimberly, Jane ,  LI, Wenlin

IPC: A61B5/103 ,  A61B5/00 ,  G01N33/52

CPC classification number: G01N33/5038 ,  G01N30/72 ,  G01N30/8631 ,  G01N33/92 ,  G01N2800/044

Abstract: The invention provides a method for identifying a compound that modulates sebum production or that modulates the amount of at least one lipid component of a sebum sample utilizing mass spectrometry.

Abstract translation: 本发明提供了一种用于鉴定调节皮脂产生的化合物或利用质谱法调节皮脂样品的至少一种脂质成分的量的方法。

公开(公告)号：WO2006090274A1

公开(公告)日：2006-08-31

申请号：PCT/IB2006/000479

申请日：2006-02-14

Applicant: WARNER-LAMBERT COMPANY LLC ,  LODAYA, Rita Mayur

Inventor： LODAYA, Rita Mayur

IPC: C07C233/07 ,  A61K31/167 ,  A61P17/08 ,  A61P17/10

CPC classification number: C07C233/07 ,  A61K31/16

Abstract: The invention is directed to the Form A polymorph of N-benzyl-N'-(2,6­diisopropyl-phenyl)-N-isopropyl-malonamide and its use as a therapeutic/cosmetic agent.

Abstract translation: 本发明涉及N-苄基-N' - （2,6-二异丙基 - 苯基）-N-异丙基 - 丙二酰胺的A型多晶型物及其作为治疗/美容剂的用途。

公开(公告)号：WO2006085196A1

公开(公告)日：2006-08-17

申请号：PCT/IB2006/000251

申请日：2006-02-01

Applicant: WARNER-LAMBERT COMPANY LLC ,  WISNER, Kyunghe, Ahn

Inventor： WISNER, Kyunghe, Ahn

IPC: C12Q1/34

CPC classification number: C12Q1/32 ,  C12Q1/34 ,  G01N2333/978 ,  G01N2500/00

Abstract: The invention provides methods for determining the activity of an ammonia­generating enzyme and methods for identifying a compound capable of modulating the activity of such an enzyme.

Abstract translation: 本发明提供了用于测定氨生成酶的活性的方法和鉴定能调节这种酶的活性的化合物的方法。

公开(公告)号：WO2006067613A1

公开(公告)日：2006-06-29

申请号：PCT/IB2005/003930

申请日：2005-12-14

Applicant: WARNER-LAMBERT COMPANY LLC ,  GARCEAU, Norman, Yves ,  WANG, Leyu ,  WISNER, Kyunghye, Ahn

Inventor： GARCEAU, Norman, Yves ,  WANG, Leyu ,  WISNER, Kyunghye, Ahn

IPC: C12N9/80 ,  C12N15/62 ,  C12N15/74

CPC classification number: C12N9/80

Abstract: The invention relates to nucleic acid compositions encoding truncated FAAH polypeptides, methods of expressing recombinant FAAH, and methods of purifying recombinant FAAH. The nucleic acid compositions comprise sequences that are optimized for transcription in a prokaryotic host.

Abstract translation: 本发明涉及编码截短的FAAH多肽的核酸组合物，表达重组FAAH的方法，以及纯化重组FAAH的方法。 核酸组合物包含针对原核宿主中的转录而优化的序列。