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    IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION
    3.
    发明申请
    IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION 审中-公开
    具有特异性实用性的改良样品管用于核酸放大

    公开(公告)号：WO2012145662A1

    公开(公告)日：2012-10-26

    申请号：PCT/US2012/034506

    申请日：2012-04-20

    申请人： STRECK, INC. ,  VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  TERMAAT, Joel, R. ,  KREIFELS, Matthew, Robert

    发明人： VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  TERMAAT, Joel, R. ,  KREIFELS, Matthew, Robert

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50825 ,  B01L7/52 ,  B01L2300/022 ,  B01L2300/043 ,  B01L2300/123 ,  B01L2300/168

    摘要： An improved tube (10) including a closure portion (12), a strap (18) integrally connected to the closure portion (12) and being configured for defining a living hinge, a body portion (20) having a longitudinal axis and an outer wall generally circumscribing the longitudinal ax is, and being integrally and hingedly connected with the closure portion (12) by way of the strap (18), the body portion (20) including a head portion (13) that has an opening (26) through which a sample is dispensed, and a sample portion (28) having a first outer wall dimension (OWD1) and including a closed distal end (30) and a wall structure (32) that includes an outer wall (34) and an inner wall structure (36) that defines a hollow cavity (38) within which the sample resides as a sample volume after is dispensed through the head portion (13), the sample portion (28) being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wail dimension (OWD1) of the sample portion (28) reduces to a smaller second outer wall dimension (OWD2).

    摘要翻译： 一种改进的管（10），包括封闭部分（12），一体地连接到封闭部分（12）并且构造成用于限定活动铰链的带子（18），具有纵向轴线的外部部分（20） 所述主体部分（20）包括具有开口（26）的头部（13），所述头部（13）具有开口（26），所述主体部分 通过其分配样品和具有第一外壁尺寸（OWD1）并包括封闭的远端（30）的样品部分（28）和包括外壁（34）和内壁（34）的壁结构 壁结构（36），其限定空心空腔（38），在所述中空空腔（38）中，所述样品部分（28）沿着所述纵向轴线大致伸长，所述样品部分（28）在所述中空空腔（38）中被分配通过所述头部部分（13） 弹性变形沿其长度的一部分，包括在a 方向，其通常横向于纵向轴线，使得壁结构的至少一部分压缩和弹性变形并且接合限定聚合酶链式反应放大装置的样品块中的开口的壁，并且与第一外壁尺寸（OWD1 ）减小到较小的第二外壁尺寸（OWD2）。

    COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE STORAGE
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE STORAGE 审中-公开
    用于生物样品储存的组合物和方法

    公开(公告)号：WO2010132508A3

    公开(公告)日：2011-03-10

    申请号：PCT/US2010034454

    申请日：2010-05-11

    申请人： BIOMATRICA INC ,  WHITNEY SCOTT E ,  ROZIERES SOHELA DE

    发明人： WHITNEY SCOTT E

    IPC分类号： C12Q1/68 ,  C07D207/04 ,  C07D239/02 ,  C12N11/02

    CPC分类号： C12Q1/6806 ,  A01N1/00 ,  A01N1/0231

    摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids,, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.

    摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下在生物样品例如核酸，蛋白质和细胞中基本上干燥储存，所述生物样品可以使用可溶性或可离解的干储存基质，其可以基本上回收样品，所述可溶性或可离解的干储存基质包含硼酸盐组合物 和所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。

    THERMOCYCLER AND SAMPLE VESSEL FOR RAPID AMPLIFICATION OF DNA
    8.
    发明申请
    THERMOCYCLER AND SAMPLE VESSEL FOR RAPID AMPLIFICATION OF DNA 审中-公开
    热释放器和样品容器用于快速扩增DNA

    公开(公告)号：WO2009105499A1

    公开(公告)日：2009-08-27

    申请号：PCT/US2009/034446

    申请日：2009-02-19

    申请人： TERMAAT, Joel R. ,  VILJOEN, Hendrik J. ,  WHITNEY, Scott E.

    发明人： TERMAAT, Joel R. ,  VILJOEN, Hendrik J. ,  WHITNEY, Scott E.

    IPC分类号： C12P19/34 ,  B01J19/00

    CPC分类号： B01L7/52 ,  B01L3/505 ,  B01L2300/043 ,  B01L2300/0627 ,  B01L2300/0838 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1844

    摘要： A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimension that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.

    摘要翻译： 用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。 将一个或多个样品容器放置在模块之间，使得容器经过模块的温度循环。 样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。 在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和除去样品流体，以及b）更薄的形状，以符合样品腔或内部空间 在热循环器的热电模块之间进行更快速的热传递。

    SAMPLE PROCESSING METHOD AND DEVICE
    10.
    发明申请
    SAMPLE PROCESSING METHOD AND DEVICE 审中-公开
    样品处理方法和装置

    公开(公告)号：WO2011153244A1

    公开(公告)日：2011-12-08

    申请号：PCT/US2011/038766

    申请日：2011-06-01

    申请人： STRECK, INC. ,  VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  FREIFELD, Alison ,  BOOTH, Christine ,  ZHAO, Xing

    发明人： VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  FREIFELD, Alison ,  BOOTH, Christine ,  ZHAO, Xing

    IPC分类号： B01L3/00 ,  C12Q1/68 ,  G01N1/40

    CPC分类号： C12Q1/6806 ,  B01L3/5023 ,  B01L3/5029 ,  B01L3/505 ,  B01L2300/0825

    摘要： The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.

    摘要翻译： 本发明提供一种用于处理和分析生物样本的方法和装置。 将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。 生物样品进一步与经处理的聚合材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。