公开(公告)号：WO9914366A3

公开(公告)日：1999-05-06

申请号：PCT/NL9800542

申请日：1998-09-18

Applicant: UNIV ERASMUS ,  DONGEN JACOBUS JOHANNES MARIA ,  PONGERS WILLEMSE MARTHA JACOBA

Inventor： VAN DONGEN JACOBUS JOHANNES MA ,  PONGERS-WILLEMSE MARTHA JACOBA

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/118

Abstract: The invention relates to the field of cancer diagnosis, more specific to the monitoring of disease development during and after treatment. The invention comprises a method for determining minimal residual disease comprising amplifying nucleic acid molecules using at least one primer reactive with a common gene segment and further comprising identifying malignancy-specific nucleic acid sequences by hybridising with a fluorogenic probe specifically and selectively reactive with said malignancy-specific nucleic acid sequences.

Abstract translation: 本发明涉及癌症诊断领域，更具体地涉及治疗期间和治疗后疾病发展的监测。 本发明包括用于确定最小残留疾病的方法，其包括使用至少一种与共同基因片段反应的引物扩增核酸分子，并且还包括通过与荧光探针杂交鉴定恶性肿瘤特异性核酸序列，并与所述恶性肿瘤特异性选择性反应， 特异性核酸序列。

公开(公告)号：WO1994003621A1

公开(公告)日：1994-02-17

申请号：PCT/EP1993001971

申请日：1993-07-23

Applicant: AKZO N.V. ,  SONDERMEIJER, Paulus, Jacobus, Antonius ,  WILLEMSE, Martha, Jacoba

Inventor： AKZO N.V.

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61K39/00 ,  C07K14/005 ,  C12N2710/16722 ,  C12N2710/16743

Abstract: The present invention is concerned with a Feline herpesvirus (FHV) mutant comprising a heterologous gene introduced into a section of the FHV genome. The invention also relates to a vector vaccine comprising such an FHV mutant which expresses a heterologous polypeptide derived from a feline pathogen and induces an adequate immune response in an inoculated host against both FHV and the feline pathogen.

Abstract translation: 本发明涉及包含引入FHV基因组部分的异源基因的猫疱疹病毒（FHV）突变体。 本发明还涉及包含这样的FHV突变体的载体疫苗，其表达源自猫科病原体的异源多肽，并且在接种的宿主中对FHV和猫病原体诱导足够的免疫应答。