公开(公告)号：WO2005095403A3

公开(公告)日：2005-12-01

申请号：PCT/US2005010494

申请日：2005-03-29

Applicant: INTERMUNE INC ,  BLATT LAWRENCE M ,  WENGLOWSKY STEVEN M ,  ANDREWS STEVEN W ,  CONDROSKI KEVIN R ,  JIANG YUTONG ,  KENNEDY APRIL L ,  DOHERTY GEORGE A ,  JOSEY JOHN A ,  STENGEL PETER J ,  WOODARD BENJAMIN T ,  MADDURU MACHENDER R

Inventor： BLATT LAWRENCE M ,  WENGLOWSKY STEVEN M ,  ANDREWS STEVEN W ,  CONDROSKI KEVIN R ,  JIANG YUTONG ,  KENNEDY APRIL L ,  DOHERTY GEORGE A ,  JOSEY JOHN A ,  STENGEL PETER J ,  WOODARD BENJAMIN T ,  MADDURU MACHENDER R

IPC: A61K31/495 ,  A61P31/12 ,  C07D487/00 ,  C07D487/04 ,  C07K5/08 ,  C07K5/083 ,  C07D209 ,  C07D245

CPC classification number: C07K5/0804 ,  C07D487/04

Abstract: The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供了大环化合物以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗黄病毒感染的方法，包括丙型肝炎病毒感染和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

公开(公告)号：WO2005095403A2

公开(公告)日：2005-10-13

申请号：PCT/US2005/010494

申请日：2005-03-29

Applicant: INTERMUNE, INC. ,  BLATT, Lawrence M. ,  WENGLOWSKY, Steven M. ,  ANDREWS, Steven W. ,  CONDROSKI, Kevin R. ,  JIANG, Yutong ,  KENNEDY, April L. ,  DOHERTY, George A. ,  JOSEY, John A. ,  STENGEL, Peter J. ,  WOODARD, Benjamin T. ,  MADDURU, Machender R.

Inventor： BLATT, Lawrence M. ,  WENGLOWSKY, Steven M. ,  ANDREWS, Steven W. ,  CONDROSKI, Kevin R. ,  JIANG, Yutong ,  KENNEDY, April L. ,  DOHERTY, George A. ,  JOSEY, John A. ,  STENGEL, Peter J. ,  WOODARD, Benjamin T. ,  MADDURU, Machender R.

IPC: C07D487/00

CPC classification number: C07K5/0804 ,  C07D487/04

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供了通式I-XIX的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗黄病毒感染的方法，包括丙型肝炎病毒感染和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。