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    CANCER BIOMARKERS AND METHODS OF USE THEREOF
    1.
    发明申请
    CANCER BIOMARKERS AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：WO2019094392A1

    公开(公告)日：2019-05-16

    申请号：PCT/US2018/059482

    申请日：2018-11-06

    申请人： X4 PHARMACEUTICALS, INC.

    发明人： WANG, Yan

    IPC分类号： C07K14/715 ,  C07K16/28 ,  G01N33/574

    摘要： The present invention relates, in part, to certain cancer biomarkers and use thereof in methods for treating cancer, such as in evaluating and/or predicting patient responses to treatment with a CXCR4 inhibitor optionally in combination with a immunotherapeutic agent, in patients with a cancer such as melanoma, including resectable and unresectable melanoma. The present invention also provides a biomarker expression platform, which is a combination of a set of genes or biomarkers that are correlated with response to a CXCR4 inhibitor in a tumor as well as a normalization gene set. A method and system of using the biomarker expression platform to derive biomarker signatures of anti-tumor response and to test patient samples for predictive biomarker signatures are also disclosed.

    METHODS FOR TREATING CANCER
    6.
    发明申请
    METHODS FOR TREATING CANCER 审中-公开
    治疗癌症的方法

    公开(公告)号：WO2017127811A1

    公开(公告)日：2017-07-27

    申请号：PCT/US2017/014578

    申请日：2017-01-23

    申请人： X4 PHARMACEUTICALS, INC.

    发明人： ARBEIT, Robert M. ,  RAGAN, Paula Marie

    IPC分类号： A61K35/17 ,  A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  C07K16/28

    CPC分类号： A61K45/06 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/4709 ,  A61K39/3955 ,  A61K2300/00

    摘要： The present invention relates to methods of treating patients with advanced forms of cancer, such as metastatic melanoma and non-small cell lung cancer, in which X4P-001 is administered as monotherapy or in combination with immune checkpoint inhibitors, such as pembrolizumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

    摘要翻译： 本发明涉及治疗患有晚期形式的癌症（例如转移性黑素瘤和非小细胞肺癌）的患者的方法，其中X4P-001作为单一疗法或与免疫检查点组合施用 抑制剂，如派姆单抗。 这些方法表现出惊人的结果，包括疾病的消退，毒性相对较小。

    METHODS FOR TREATING CANCER
    8.
    发明申请
    METHODS FOR TREATING CANCER 审中-公开

    公开(公告)号：WO2018237158A1

    公开(公告)日：2018-12-27

    申请号：PCT/US2018/038776

    申请日：2018-06-21

    申请人： X4 PHARMACEUTICALS, INC.

    发明人： PARASURAMAN, Sudha ,  WANG, Yan

    IPC分类号： A61K31/4709 ,  A61K39/395 ,  A61P35/00 ,  A61P37/04

    摘要： The present invention relates to methods of treating cancer, in which a CXCR4 inhibitor such as X4P-001 or a pharmaceutically acceptable salt thereof or pharmaceutical composition thereof is administered in combination with an additional therapeutic agent, such as an immune checkpoint inhibitor. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

    METHODS FOR TREATING CANCER
    10.
    发明申请
    METHODS FOR TREATING CANCER 审中-公开
    治疗癌症的方法

    公开(公告)号：WO2017177230A1

    公开(公告)日：2017-10-12

    申请号：PCT/US2017/026819

    申请日：2017-04-10

    申请人： X4 PHARMACEUTICALS, INC.

    发明人： ARBEIT, Robert, D.

    IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06

    摘要： The present invention relates to methods of treating patients with advanced forms of cancer, such as unresectable or metastatic renal cell carcinoma or kidney cancer, in which X4P-001 or a pharmaceutically acceptable salt thereof is administered as monotherapy or in combination with an immune checkpoint inhibitor, such as nivolumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

    摘要翻译： 本发明涉及治疗患有晚期形式的癌症（例如不可切除或转移性肾细胞癌或肾癌）的患者的方法，其中X4P-001或其药学上可接受的盐作为单一疗法施用 或与免疫检查点抑制剂如nivolumab组合。 这些方法表现出惊人的结果，包括疾病的消退，毒性相对较小。