公开(公告)号：WO2012135332A1

公开(公告)日：2012-10-04

申请号：PCT/US2012/030923

申请日：2012-03-28

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  TUFTS MEDICAL CENTER, INC. ,  HU, Guofu ,  YU, Wenhao

Inventor： HU, Guofu ,  YU, Wenhao

IPC: C07K16/30 ,  C12P21/08 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/71 ,  C07K14/715 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/6863

Abstract: Disclosed herein are novel compositions and methods for the inhibition of Plexin B2- mediated Angiogenin activity. Such compositions and methods are useful, for example, for the treatment of cancer, the treatment of wet AMD and the inhibition of angiogenesis. Also disclosed herein are methods of determining whether a test agent is a modulator of Plexin B2 activity.

Abstract translation: 本文公开了用于抑制Plexin B2介导的血管生成素活性的新型组合物和方法。 这样的组合物和方法可用于例如治疗癌症，治疗湿性AMD和抑制血管发生。 本文还公开了确定测试剂是否是Plexin B2活性的调节剂的方法。