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    PROTEIN-POLYPEPTIDE COMPLEX WITH A SPECIFIC EFFECT ON SKIN TISSUE, METHOD FOR PRODUCING SAID COMPLEX AND PHARMACEUTICAL COMPOSITION ON THE BASIS THEREOF
    1.
    发明申请
    PROTEIN-POLYPEPTIDE COMPLEX WITH A SPECIFIC EFFECT ON SKIN TISSUE, METHOD FOR PRODUCING SAID COMPLEX AND PHARMACEUTICAL COMPOSITION ON THE BASIS THEREOF 审中-公开
    具有对皮肤组织的特异性影响的蛋白多肽复合物，其基础上生产复合物和药物组合物的方法

    公开(公告)号：WO2012166006A1

    公开(公告)日：2012-12-06

    申请号：PCT/RU2012000141

    申请日：2012-02-28

    Applicant: ZAKRYTOE AKTSIONERNOE OBSCHESTVO PHARM SINTEZ ,  NAZARENKO ANNA BORISOVNA ,  SOKOLOV MIKHAIL ANATOLEVICH

    Inventor： NAZARENKO ANNA BORISOVNA ,  SOKOLOV MIKHAIL ANATOLEVICH

    IPC: C07K2/00 ,  A61K35/30 ,  A61K35/36 ,  A61K38/02 ,  A61P17/00 ,  C07K1/14

    CPC classification number: A61K35/54 ,  A61K8/64 ,  A61K8/982 ,  A61K35/30 ,  A61K35/36 ,  A61K38/02 ,  A61Q19/08

    Abstract: The invention relates to biotechnology. The protein-polypeptide complex which has a tissue-specific regenerative, reparative and rejuvenating effect on skin tissue is produced from nerve and skin tissues of embryos of hoofed agricultural animals within a gestation period from the middle of the first trimester to the middle of the final trimester of pregnancy by homogenizing said tissue in a buffer solution with simultaneous extraction in the presence of reversible proteolysis inhibitors, non-ionic detergents and solubilizers at a pH of 5.2-8.5. The homogenate produced is centrifuged and filtered. The proteins are separated out on a chromatography column using an anion-exchange medium. The fractions produced are combined and subjected to sterilizing filtration. The complex comprises negatively charged, weakly acid, neutral proteins and polypeptides having molecular masses of from 0.5 to 200 kDa. The complex is characterized by an absorption peak at a wavelength of 215±5 nm upon plotting of the ultraviolet spectrum in a wavelength range of from 200 to 500 nm. The pharmaceutical composition comprises, as active ingredient, the protein-polypeptide complex in a concentration of 0.01-2.0 mg/ml, polynucleotides in the form of a sodium salt of deoxyribonucleic acid, and a pharmaceutically acceptable diluent.

    Abstract translation: 本发明涉及生物技术。 具有组织特异性再生，修复和恢复肌肤组织功能的蛋白质 - 多肽复合体，在妊娠期妊娠期至妊娠中期的蹄动物胚胎的神经和皮肤组织产生。 在可逆蛋白水解抑制剂，非离子洗涤剂和增溶剂的存在下，在pH为5.2-8.5的同时萃取的同时，将缓冲液中的所述组织匀浆化，以妊娠三个月。 将生成的匀浆离心并过滤。 使用阴离子交换介质在色谱柱上分离蛋白质。 将生成的级分合并进行灭菌过滤。 络合物包含分子量为0.5至200kDa的带负电荷的弱酸性中性蛋白质和多肽。 该复合物的特征在于在200-500nm的波长范围内绘制紫外光谱时，波长为215±5nm处的吸收峰。 药物组合物包含浓度为0.01-2.0mg / ml的蛋白质 - 多肽复合物作为活性成分，为脱氧核糖核酸的钠盐形式的多核苷酸和药学上可接受的稀释剂。

    QUINOLINE DERIVATIVES AND METHOD FOR PRODUCING AND USING SAME
    2.
    发明申请
    QUINOLINE DERIVATIVES AND METHOD FOR PRODUCING AND USING SAME 审中-公开
    喹啉衍生物及其制备方法和使用方法

    公开(公告)号：WO2013039428A3

    公开(公告)日：2013-05-10

    申请号：PCT/RU2012000725

    申请日：2012-09-04

    Applicant: ZAKRYTOE AKTSIONERNOE OBSCHESTVO PHARM SINTEZ ,  NAZARENKO ANNA BORISOVNA ,  FEDOROV VLADIMIR EGOROVICH ,  ILIIN VADIM EGOREVICH ,  OMELKOV ANTON VLADIMIROVICH ,  RUCHKO EVSEJ ALEKSANDROVICH

    Inventor： NAZARENKO ANNA BORISOVNA ,  FEDOROV VLADIMIR EGOROVICH ,  ILIIN VADIM EGOREVICH ,  OMELKOV ANTON VLADIMIROVICH ,  RUCHKO EVSEJ ALEKSANDROVICH

    IPC: C07D215/18 ,  A61K31/47 ,  A61P31/06

    CPC classification number: C07D215/18 ,  C07D215/20 ,  C07D491/056

    Abstract: The present invention relates to novel quinoline derivatives, such as substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1- phenylbutan-2-ols, to a method for producing same, and also to the use thereof as antimycobacterial agents, in particular to 5,6,7-substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1- phenylbutan-2-ols of general formula (I), where R1 is Н or methoxy, R2 is Н, methoxy or -O-(CH2)n-O-, R3 is Н, methoxy or -O-(CH2)n-O-, n=1-2, and also to the pharmaceutically acceptable salts thereof with acids which exhibit activity in relation to mycobacteria. The invention also relates to a method for producing compounds of formula (I), which consists in interacting corresponding arylquinolines with an aromatic ketone and using said compounds as an active principle in the creation of anti-tubercular medicinal preparations.

    Abstract translation: 本发明涉及新颖的喹啉衍生物，例如取代的1-（2-氯喹啉-3-基）-4-二甲基氨基-2-（萘-1-基）-1-苯基丁-2-醇， 以及作为抗分枝杆菌剂的用途，特别是5,6,7-取代的1-（2-氯喹啉-3-基）-4-二甲基氨基-2-（萘-1-基）-1 （I）的苯基丁-2-醇，其中R 1是Н或甲氧基，R 2是Н，甲氧基或-O-（CH 2）n O-，R 3是Н，甲氧基或-O-（CH 2）n O-， n = 1-2，并且其药学上可接受的盐与表现出与分枝杆菌有关的活性的酸。 本发明还涉及一种制备式（I）化合物的方法，其包括将相应的芳基喹啉与芳族酮相互作用，并使用所述化合物作为抗结核药物制剂的产生的活性成分。

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