公开(公告)号：WO2018067532A1

公开(公告)日：2018-04-12

申请号：PCT/US2017/054892

申请日：2017-10-03

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： O'HARE, Jonathan J. ,  PEKUROVSKY, Mikhail L. ,  DETERMAN, Amy S. ,  PITERA, Gino L. ,  BJORK, Jason W. ,  NORTON, Daniel V. ,  ASMUS, Robert A.

IPC: A61F13/00 ,  B32B37/24 ,  A61L15/32

Abstract: A method of forming a fibrin hydrogel composition including providing one or more unitary masses of a fibrin hydrogel, dividing at least one of the unitary masses of the fibrin hydrogel into a multiplicity of smaller pieces of the fibrin hydrogel, and recombining at least a portion of the smaller pieces into a cohesive mass. Dividing at least one of the unitary masses of fibrin hydrogel into a multiplicity of smaller pieces may include shearing or cutting the unitary masses to form an aqueous dispersion of the fibrin hydrogel in an aqueous medium. The aqueous dispersion of fibrin hydrogel may be applied to a substrate on a roller or an endless belt, and is optionally overlaid by a scrim. The cohesive mass of fibrin hydrogel, which may be formed by removing at least a portion of the aqueous medium from the aqueous dispersion of the smaller pieces of the fibrin hydrogel, finds uses in wound dressing articles.

Abstract translation: 一种形成纤维蛋白水凝胶组合物的方法，包括提供一个或多个纤维蛋白水凝胶的单一团块，将纤维蛋白水凝胶的单一团块中的至少一个分成多个纤维蛋白水凝胶的较小片段 并且将至少一部分小块重新组合成粘性物质。 将至少一个单一纤维蛋白水凝胶块分成多个小块可包括剪切或切割整体块以形成纤维蛋白水凝胶在水性介质中的水分散体。 纤维蛋白水凝胶的水分散体可以施加到辊或环形带上的基底上，并且任选地被稀松布覆盖。 可以通过从纤维蛋白水凝胶的较小部分的水分散体中除去至少一部分水性介质而形成的纤维蛋白水凝胶的粘着块可用于伤口敷料制品。