公开(公告)号：WO2019053634A1

公开(公告)日：2019-03-21

申请号：PCT/IB2018/057020

申请日：2018-09-13

Applicant: ABBVIE S.À.R.L. ,  GALAPAGOS NV

Inventor： ALTENBACH, Robert J. ,  BOGDAN, Andrew ,  COUTY, Sylvain ,  DESROY, Nicolas ,  GFESSER, Gregory A. ,  HOUSSEMAN, Christopher Gaëtan ,  KYM, Philip R. ,  LIU, Bo ,  MAI, Thi Thu Trang ,  MALAGU, Karine Fabienne ,  MERAYO MERAYO, Nuria ,  PICOLET, Olivier Laurent ,  PIZZONERO, Mathieu Rafaël ,  SEARLE, Xenia B. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  YEUNG, Ming C.

IPC: C07D213/71 ,  C07D215/36 ,  C07D231/56 ,  C07D401/12 ,  C07D235/28 ,  C07D471/04 ,  C07D213/64 ,  C07C311/45 ,  A61P11/00 ,  A61K31/4709

Abstract: The invention discloses compounds of Formula (I), wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

公开(公告)号：WO2019193062A1

公开(公告)日：2019-10-10

申请号：PCT/EP2019/058417

申请日：2019-04-03

Applicant: ABBVIE S.Á.R.L ,  GALAPAGOS NV

Inventor： DESROY, Nicolas ,  DE LEMOS, Elsa ,  COUTY, Sylvain ,  PICOLET, Olivier Laurent ,  WANG, Xueqing ,  SEARLE, Xenia B ,  LIU, Bo ,  YEUNG, Ming C. ,  ALTENBACH, Robert J ,  GFESSER, Gregory A. ,  KYM, Phillip R.

IPC: C07D403/04 ,  C07D403/06 ,  C07D407/06 ,  C07D207/16 ,  A61K31/4025 ,  A61P11/00

Abstract: The invention discloses compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 3A , R 4 , and R 5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.