公开(公告)号：WO2022197564A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020074

申请日：2022-03-11

Applicant: ACADEMIA SINICA ,  LIU, Fu-Tong

Inventor： CHENG, Wei-Chieh ,  CHEN, Wei-An ,  CHEN, Yu-Hsin ,  CHENG, Ting-Jen ,  SHEN, Chia-Ning ,  HSIEH, Chiao-Yun ,  HUNG, Pi-Fang

IPC: A61K31/395 ,  A61K31/40 ,  A61K31/407 ,  C07D403/02 ,  C07D487/00 ,  C07D487/04

Abstract: Disclosed herein are novel polyhydroxylated indolizidine and pyrrolizidine derivates and methods for using the same in the treatment of cancer. The present poly hydroxylated indolizidine and pyrrolizidine derivates has the structure of formula (I), wherein: X is 0 or S; a, b and c are independently an integral of 0 or 1; and R is selected from the group consisting of H, C1-6 alkyl, alkenyl, alkynyl, and, heteroawl, cycloalkyl. cycloalkenyl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl, heteroaralkynyl. heterocyclyl, alkoxy, aryloxy, and sulfonyl.