公开(公告)号：WO2018035125A1

公开(公告)日：2018-02-22

申请号：PCT/US2017/046949

申请日：2017-08-15

Applicant: ACADEMIA SINICA ,  SHIH, Ming-Che

Inventor： CHEN, Pao-Yang ,  YEN, Ming-Ren ,  HSU, Fei-Man ,  LEE, Yi-Jing

IPC: C12Q1/68

CPC classification number: C12Q1/6858 ,  C12Q2521/331 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: The invention relates to methods of utilizing epigenetic information to separate one type of DNA from a mixture of multiple DNAs. The applications of the methods of the invention include, for example, the detection of chromosomal abnormality (e.g., aneuploidy, cancer cells), identification of genome abnormality, direct detection of DNA with abnormal copy number and development of indicators for the above-mentioned detection and identification.

Abstract translation: 本发明涉及利用表观遗传信息从多种DNA的混合物中分离出一种类型的DNA的方法。 本发明方法的应用包括例如染色体异常（例如非整倍性，癌细胞）的检测，基因组异常的鉴定，具有异常拷贝数的DNA的直接检测和用于上述检测的指示剂的开发 和鉴定。