公开(公告)号：WO2013086218A1

公开(公告)日：2013-06-13

申请号：PCT/US2012/068284

申请日：2012-12-06

Applicant: ACUITAS MEDICAL LIMITED

Inventor： CHASE, David, R. ,  JAMES, Timothy, W. ,  FARR, Lance, W.

IPC: G01R33/483 ,  G01R33/54 ,  G01N24/08

CPC classification number: G01R33/54 ,  G01N24/081 ,  G01R33/4833

Abstract: A method of assessing a spatial frequency distribution within a sample comprising subjecting the sample to magnetic resonance excitation, receiving an echo signal from the sample while the sample is subjected to a magnetic field gradient, applying an invertible linear transform to the echo signal, identifying a region of interest in the transformed echo signal and deriving a corresponding window function, applying the window function (in the signal or transform domain) to the echo signal to remove echo signal coming from regions of the sample outside of the region of interest, and analyzing the one dimensional spatial frequency content in the windowed echo signal in order to access a one dimensional spatial frequency distribution within the region of interest within the sample without creating an image.

Abstract translation: 一种评估样本内的空间频率分布的方法，包括使样本进行磁共振激励，在样本经受磁场梯度的同时接收来自样本的回波信号，对回波信号应用可逆线性变换， 在变换的回波信号中感兴趣的区域并导出对应的窗口函数，将窗函数（在信号或变换域中）应用于回波信号，以去除来自感兴趣区域外的样本区域的回波信号，并分析 窗口回波信号中的一维空间频率内容，以便在样本内访问感兴趣区域内的一维空间频率分布，而不产生图像。

公开(公告)号：WO2013040086A1

公开(公告)日：2013-03-21

申请号：PCT/US2012/054934

申请日：2012-09-12

Applicant: ACUITAS MEDICAL LIMITED ,  JAMES, Timothy, W. ,  JAMES, Kristin ,  FARR, Lance, W. ,  CHASE, David, R. ,  BRADY, J., Michael ,  RAFFERTY, James ,  HEINRICH, John, P.

Inventor： JAMES, Timothy, W. ,  JAMES, Kristin ,  FARR, Lance, W. ,  CHASE, David, R. ,  BRADY, J., Michael ,  RAFFERTY, James ,  HEINRICH, John, P.

IPC: G01R33/483 ,  G01R33/56 ,  A61B5/055

CPC classification number: A61B5/0555 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4088 ,  A61B2576/026 ,  G01R33/483 ,  G01R33/4833 ,  G01R33/5601 ,  G01R33/5608

Abstract: The disclosed invention is a method for detecting indications of the presence of Alzheimer's disease (AD) and related dementia-inducing, motor-control-related pathologies, and other diseases in the human brain using a magnetic-resonance based technique for measuring fine tissue and bone textures. Specifically, the invention focuses on refinements/adaptations to a prior art magnetic resonance fine texture measurement technique that facilitates/enables pushing the detection limits closer to the cellular level, so as to be able to measure the fine scale structures and tissue changes that are known to be characteristic of the neurodegenerative processes involved in the development of these diseases.

Abstract translation: 所公开的发明是使用基于磁共振的技术来测量精细组织的方法，用于检测人脑中阿尔茨海默氏病（AD）和相关的痴呆诱导，运动控制相关病理学和其他疾病的存在的指征， 骨纹理。 具体地，本发明着重于对现有技术的磁共振细纹理测量技术的改进/适应，其有利于/能够将检测限度推到更接近细胞水平，以便能够测量已知的细小尺度结构和组织变化 是涉及这些疾病发展的神经变性过程的特征。