公开(公告)号：WO2023091372A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/049827

申请日：2022-11-14

申请人： ACULON, INC.

发明人： HANSON, Eric L.

IPC分类号： C09D4/00 ,  C09D133/26 ,  C09D5/16 ,  C08F220/56

摘要： Coated articles and medical devices are provided comprising: (a) a substrate with a surface having reactive functional groups; (b) a polymerization initiator chemically bonded to the substrate via reaction with the reactive functional groups on the surface of the substrate; and (c) a polymeric coating layer having a thickness greater than 10 nanometers and less than 2.5 microns. The polymeric coating layer is prepared from an aqueous monomer composition comprising at least 50 percent by weight of at least one (meth)acrylamide monomer having at least one ionic functional group. The polymeric coating layer is chemically bonded to and propagated from the polymerization initiator, and the polymeric coating layer demonstrates a water contact angle less than 10 degrees. The coated article retains a contact angle of less than 10 degrees after immersion in phosphate buffered aqueous saline solution at 22°C for a period of 28 days.