公开(公告)号：WO2018117973A1

公开(公告)日：2018-06-28

申请号：PCT/SG2017/050639

申请日：2017-12-22

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

发明人： BRZOZOWSKA, Agata Maria ,  ANTIPINA, Maria N.

IPC分类号： B01J13/10

摘要： The present invention relates to a method of encapsulating an uncharged, soluble, active compound within a self- assembled ionomer complex formed from polyelectrolytes, wherein the said method comprises the steps of mixing a solution comprising at least one polycation and polyanion with active compound, or adding a polyion to a solution comprising an oppositely charged polyion coupled to the active compound, wherein the interaction between the active compound and ionomer complex is non-ionic and non-covalent in nature. The invention also relates to an ionomer complex prepared thereform for use in transport and delivery of the compounds. In a preferred embodiment, the ionomer complex comprises poly-L-arginine, Poly(ethylene oxide)-b-poly(acrylic acid) (PAA-b-PEO), wherein the said ionomer encapsulates 4-methoxyphenyl β-D-glucopyranoside (MG).