公开(公告)号：WO2023057870A1

公开(公告)日：2023-04-13

申请号：PCT/IB2022/059394

申请日：2022-10-03

申请人： AGRESEARCH LIMITED

发明人： UMAIR, Saleh ,  KNIGHT, Jacqueline Sarah

IPC分类号： A61P33/10 ,  A61K39/00 ,  C07K14/435 ,  C12N15/70 ,  C12N9/12 ,  C12N9/88

摘要： The present invention is directed to a vaccine comprising recombinant antigens derived from the parasitic nematode Haemonchus contortus, which will raise an immune response in farmed and wild ruminants that are susceptible or predisposed to infection by one or more nematode worm species. The recombinant antigens used in the invention are conserved among species of nematode worms so that the vaccine will provide protection against multiple types of nematode worms. In particular, the invention provides a composition or vaccine composition comprising the recombinant H. contortus antigens: (i) enolase (EN); (ii) arginine kinase (AK); and (iii) ornithine decarboxylase (ODC), or antigenic fragments thereof, together with a veterinary acceptable carrier or diluent.