公开(公告)号：WO2020214631A1

公开(公告)日：2020-10-22

申请号：PCT/US2020/028191

申请日：2020-04-15

申请人： AGRIMETIS, LLC ,  GREEN, Brian Michael

发明人： GREEN, Brian Michael ,  WITEK, Rachel Melissa ,  PAVLOVA, Nadejda ,  OBERHOLZER, Matthew Richard

IPC分类号： C07F9/30 ,  C12P41/00 ,  C12N9/06

摘要： Methods for preparing crystalline L-glufosinate ammonium monohydrate are disclosed. The methods include forming a mixture comprising water, a water-miscible organic solvent, ammonium hydroxide, and a glufosinate starting material containing L-glufosinate ammonium and D-glufosinate ammonium. L-Glufosinate ammonium monohydrate is crystallized and separated from the mixture, providing L-glufosinate ammonium monohydrate Form B. Compositions and methods employing the crystalline L-glufosinate ammonium monohydrate are also described.

公开(公告)号：WO2019018406A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/042503

申请日：2018-07-17

申请人： AGRIMETIS, LLC

发明人： FIELDS, Stephen Craig ,  OBERHOLZER, Matthew Richard ,  GREEN, Brian Michael ,  KULKARNI, Samir ,  NELSON, Jennifer ,  ANDRES, Patricia

IPC分类号： A01N57/20 ,  B01D15/36 ,  G01N23/207

摘要： Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.