公开(公告)号：WO2021161047A1

公开(公告)日：2021-08-19

申请号：PCT/GB2021/050360

申请日：2021-02-12

申请人： ALMAC DISCOVERY LIMITED

发明人： JACQ, Xavier ,  LOBB, Ian Thomas ,  WAPPETT, Mark ,  JURISIC, Anamarija ,  ROUNTREE, James Samuel Shane ,  HELM, Matthew Duncan

IPC分类号： A61K31/522 ,  A61K31/513 ,  A61K31/53 ,  A61K31/4025 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/497 ,  A61K31/498 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04

摘要： Provided herein are treatments for cancer by inhibition of USP7 activity, for example inhibition of USP7 activity in fibroblasts, inhibition of extra-cellular matrix remodelling in the tumour microenvironment, inhibition of VEGF, inhibition of angiogenesis or metastasis, modulation of the immune system, or a combination thereof.