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公开(公告)号:WO2014089335A2
公开(公告)日:2014-06-12
申请号:PCT/US2013/073382
申请日:2013-12-05
Applicant: AMGEN INC.
Inventor: ARMITAGE, Richard J. , BLAKE, Michelle , FANSLOW, III, William C. , O'NEILL, Jason Charles , KANNAN, Gunasekaran , XU, Jiangchun , TOMETSKO, Mark Edward , WANG, Zhulun , SUDOM, Athena
CPC classification number: C07K16/2878 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.
Abstract translation: 本发明涉及BCMA(B细胞成熟抗原)抗原结合蛋白,例如抗体,编码所述抗原结合蛋白的多核苷酸序列,以及用于诊断和治疗疾病的组合物和方法。 本发明还涉及BCMA抗体药物共轭物及其用途。