公开(公告)号：WO2003070727A1

公开(公告)日：2003-08-28

申请号：PCT/US2003/004537

申请日：2003-02-13

Applicant: AMGEN INC.

Inventor： SANTORA, Vincent ,  ASKEW, Benny, C. ,  DE MORIN, Frenel, F. ,  HAGUE, Andrew ,  LABER, Ellen ,  LI, Aiwen ,  LIU, Gang ,  LOPEZ, Patricia ,  NOMAK, Rana ,  TEGLEY, Christopher ,  YANG, Kevin

IPC: C07D417/14

CPC classification number: C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/06 ,  C07D471/04 ,  C07D491/10

Abstract: Selected thiazolyl urea compounds of formula (VI) are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 式（VI）的选择的噻唑基脲化合物对于预防和治疗诸如细胞增殖或细胞凋亡介导的疾病的疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及stoke，癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。