公开(公告)号：WO2016003813A1

公开(公告)日：2016-01-07

申请号：PCT/US2015/038049

申请日：2015-06-26

Applicant: AMGEN INC.

Inventor： FOLK, Christopher, R. ,  GIBSON, Scott, R. ,  INTOCCIA, Brian, J.

IPC: A61M5/20 ,  A61M5/31

CPC classification number: A61M5/20 ,  A61M5/31571 ,  A61M5/31576 ,  A61M5/3245 ,  A61M2005/2013 ,  A61M2005/3143

Abstract: An injection device, method, and system for drug delivery includes a container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug; an injection drive mechanism having a plunger for acting on the stopper and an energy source having a first selected potential energy for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug; and a plunger loading mechanism for substantially preventing the plunger from accelerating to a predetermined velocity before it acts on the stopper. The plunger loading mechanism may be a spring having a second selected potential energy for reducing or eliminating a distance between the plunger and the stopper, prior to the plunger accelerating to the velocity. The second selected potential energy of the spring may be less than the first selected potential energy of the energy source.

Abstract translation: 用于药物递送的注射装置，方法和系统包括用于储存药物的容器，所述容器具有可移动地设置在容器中用于排出药物的塞子; 注射驱动机构，其具有用于作用在止动器上的柱塞和具有第一选择的势能的能量源，用于在柱塞上施加力以使柱塞作用在塞子上以排出药物; 以及柱塞装载机构，用于在其作用在止动器上之前基本上防止柱塞加速到预定速度。 柱塞加载机构可以是在柱塞加速到速度之前具有用于减小或消除柱塞和止动器之间的距离的第二选择的势能的弹簧。 弹簧的第二选择的势能可能小于能量源的第一选择势能。