公开(公告)号：WO2020023268A1

公开(公告)日：2020-01-30

申请号：PCT/US2019/042234

申请日：2019-07-17

Applicant: AMGEN INC.

Inventor： YU, Xin ,  OUYANG, Wenjun ,  LI, Chi-Ming Kevin ,  EGEN, Jackson Graeme ,  YOON, Oh Kyu ,  DRIVER, Ian Halsey ,  TAKENAKA, Shunsuke ,  THOMSON, Christy Ann ,  WANG, Hongyu

IPC: C07K16/28 ,  A61K39/395

Abstract: This invention relates to combination therapies comprising a Programmed Death 1 receptor (PD-1) pathway inhibitor, and a Leukocyte Immunoglobulin Like Receptor B (LILRB) signaling inhibitor, and the use of the combination therapies for the treatment of cancer. The invention also relates to the treatment of cancer patients who are refractory to monotherapy with a PD-1 pathway inhibitor.

公开(公告)号：WO2020263793A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/039079

申请日：2020-06-23

Applicant: AMGEN INC.

Inventor： HU, Ruozhen ,  MANZANILLO, Paolo ,  OUYANG, Wenjun

IPC: A61K38/17 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are methods of treating a subject with a tumor or cancer. In exemplary embodiments, the method comprises increasing an immune response against the tumor or cancer in the subject or increasing effector activity or reducing suppressive activity of T-cells in the subject. In exemplary embodiments, the method comprises administering to the subject a SIRPγ binder, e.g ., SIRPγ inhibitor, in an amount effective to treat the tumor or cancer in the subject.

公开(公告)号：WO2021127262A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/065734

申请日：2020-12-17

Applicant: AMGEN INC.

Inventor： CHAUDRHY, Ashutosh ,  OUYANG, Wenjun

IPC: C07K16/24 ,  C07K14/55 ,  C07K16/28 ,  A61K2039/505 ,  A61K38/191 ,  A61K38/2013 ,  A61K39/39 ,  A61P37/04 ,  C07K16/2878 ,  C07K2317/75 ,  C07K2319/30 ,  C07K2319/75 ,  C12N2501/2302 ,  C12N2501/25 ,  C12N5/0637

Abstract: Provided herein are combinations of an IL-2 molecule or mutein and a TNFR agonist, and complexes comprising IL-2/TNFR agonist molecules, such as Fc-bound IL-2/TNFR agonist molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are methods of making and using the compositions of the disclosure